A Percutaneous Delivery System for a Nicotinamide Transdermal Therapeutic System

—A percutaneous delivery system for nicotinamide is developed and its functional properties are studied in vitro. Four compositions of the emulsion percutaneous delivery system for a nicotinamide transdermal therapeutic system (TTS) are suggested, in which the amount of the percutaneous carrier, docusate sodium, is varied. The performed studies of the diffusion of nicotinamide in vitro through unpreserved rabbit skin show that increasing the concentration of docusate sodium threefold (from 3.3 up to 9.8%) significantly increases the amount of the diffused drug substance by ~15% and decreases its residual concentration in the TTS. The amount of the antioxidant detected in the skin flap is lower than the therapeutic dose (~1.46% of its initial amount in the TTS) within 24 h after the start of the in vitro experiment, which indicates the absence of a possible aftereffect of the nicotinamide TTS in its clinical use after detaching from the patient’s skin.