Preparation and characterization of various PVPylated divalent metal-doped ferrite nanoparticles for magnetic hyperthermia

There is an incessant demand to keep improving on the heating responses of polymeric magnetic nanoparticles (MNPs) under magnetic excitation, particularly in the pursuit for them to be utilized for clinical hyperthermia applications. Herein, we report the fabrication of a panel of PVP-capped divalent metal-doped MFe 2 O 4 (M ≅ Co, Ni, Zn, Mg, and Sn) MNPs prepared via the Ko-precipitation Hydrolytic Basic (KHB) methodology and assess their magneto-thermal abilities. The physiochemical, structural, morphological, compositional, and magnetic properties of the doped ferrites were fully characterized using various techniques mainly TEM, XRD, EDX, FTIR, and VSM. The obtained doped MNPs exhibited stabilized quasi-spherical sized particles (10-17 nm), pure well-crystallized cubic spinel phases, and high saturation magnetizations ( M s = 26-81 emu g −1 ). In response to a clinically-safe alternating magnetic field (AMF) ( f = 332.8 kHz and H = 170 Oe), distinctive heating responses of these doped ferrites were attained. Hyperthermia temperatures of 42 °C can be reached very fast in only ∼5 min, with heating temperatures slowly increasing to reach up to 55 °C. The highest heating performance was observed for PVP-NiFe 2 O 4 and the lowest for PVP-Sn-doped NPs (SAR values: PVP-NiFe 2 O 4 > PVP-CoFe 2 O 4 > PVP-ZnFe 2 O 4 > PVP-MgFe 2 O 4 > PVP-SnFe 2 O 4 ). This trend was found to be directly correlated to their observed magnetic saturation and anisotropy. Heating efficiencies and specific SAR values as functions of concentration, frequency, and amplitude were also systematically investigated. Finally, cytotoxicity assay was conducted on aqueous dispersions of the doped ferrite NPs, proving their biocompatibility and safety profiles. The PVPylated metal-doped ferrite NPs prepared here, particularly Ni- and Co-doped ferrites, are promising vehicles for potential combined magnetically-triggered biomedical hyperthermia applications. We report the preparation of a panel of biocompatible PVPylated divalent metal-doped MFe 2 O 4 (M= Co, Ni, Zn, Mg, and Sn) ferrites and assess their magneto-thermal abilities for hyperthermia applications. The heating performance directly correlated to their observed magnetic saturation and anisotropy.