Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targeting by Wormlike Polymer Micelles (Small 21/2024)

Wormlike Polymer Micelles In article number 2306482, Andreas Stallmach, Johannes C. Brendel, and co‐workers found that wormlike polymer micelles in contrast to spherical structures translocate selectively into inflamed intestinal mucosa without affecting healthy tissue. Entering the lamina propria,...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2024-05, Vol.20 (21), p.n/a
Hauptverfasser:	Gardey, Elena, Cseresnyes, Zoltan, Sobotta, Fabian H., Eberhardt, Juliane, Haziri, Drilon, Grunert, Philip C., Kuchenbrod, Maren T., Gruschwitz, Franka V., Hoeppener, Stephanie, Schumann, Michael, Gaßler, Nikolaus, Figge, Marc T., Stallmach, Andreas, Brendel, Johannes C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Immune system inflammatory bowel disease (IBD) Micelles nanoparticles Polymers shape control Side effects targeted delivery Ussing chambers
Online-Zugang:	Volltext
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Zusammenfassung:	Wormlike Polymer Micelles In article number 2306482, Andreas Stallmach, Johannes C. Brendel, and co‐workers found that wormlike polymer micelles in contrast to spherical structures translocate selectively into inflamed intestinal mucosa without affecting healthy tissue. Entering the lamina propria, the micelles further passively target only immune cells of the inflamed biopsy, which is key for effective treatment of IBD and elimination of drug‐related side effects.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.202470162