A Review of Fabrication of DNA Origami Plasmonic Structures for the Development of Surface-Enhanced Raman Scattering (SERS) Platforms

The label-free, non-destructive information provided by Raman spectroscopy regarding chemical composition, molecular structure, and molecular interaction makes it a potent analytical tool. Raman scattering’s low intensity, however, prevents it from being widely used in a variety of sectors. Plasmonic nanoparticles (NPs) on the surface may considerably improve the Raman process, resulting in surface-enhanced Raman scattering (SERS). Due to the capacity to co-assembling many particles in complicated shapes with fine control of stoichiometry, orientation, and gaps between the particles, the creation of plasmonic nanostructures utilizing a bottom-up method using DNA origami has generated considerable scientific interest. We evaluate current developments in the use of DNA origami structures for the creation of SERS-based sensors in this review paper. We go through SERS fundamentals, plasmonic enhancement processes, and several plasmonic nanostructure fabrication techniques. Additionally, we discuss the benefits of DNA origami in the construction of plasmonic NPs and the creation of SERS hotspots for analytical and medicinal uses. We also discuss potential paths for future research and difficulties facing DNA origami-based SERS sensors. This study attempts to provide a thorough grasp of DNA origami’s potential in the creation of SERS-based sensors and its possibilities for the future.