Synthesis and Properties of N,N′-Disubstituted Ureas and Their Isosteric Analogs Containing Polycyclic Fragments: XIX. exo-Isomers of N-(1,7,7-Trimethylbicyclo[2.2.1]heptan-2-yl)-N′-R-ureas and -thioureas

N , N ′-Disubstituted ureas and thioureas containing a 1,1,7-trimethylbicyclo[2.2.1]heptan-2-yl sub­stit­uent were synthesized in up to 99% yields by the reaction of exo -( R or S )-1,1,7-trimethylbicyclo[2.2.1]­heptan-2-amine with aromatic isocyanates and isothiocyanates with the goal of comprehensive estimation of enantiomeric stereospecificity of human soluble epoxide hydrolase (hsEH). The synthesized compounds are promising hsEH inhibitors.