Synthesis of Amides Based on Biologically Active (5Z,9Z)-Eicosa-5,9-dienoic Acid

Synthesis of Amides Based on Biologically Active (5Z,9Z)-Eicosa-5,9-dienoic Acid

New amides of (5Z,9Z)-eicosa-5,9-dienoic acid, which is a highly active topoisomerase I/II inhibi­tor, were synthesized via Cp 2 TiCl 2 -catalyzed intermolecular cross-cyclomagnesiation of aliphatic and oxygen-containing 1,2-dienes as the key step.

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Veröffentlicht in:Russian journal of organic chemistry 2024-03, Vol.60 (3), p.437-441
Hauptverfasser: Makarova, E. Kh, Makarov, A. A., Dzhemilev, U. M., D’yakonov, V. A.
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Chemical synthesis
Chemistry
Chemistry and Materials Science
Dienes
Organic Chemistry
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Zusammenfassung:New amides of (5Z,9Z)-eicosa-5,9-dienoic acid, which is a highly active topoisomerase I/II inhibi­tor, were synthesized via Cp 2 TiCl 2 -catalyzed intermolecular cross-cyclomagnesiation of aliphatic and oxygen-containing 1,2-dienes as the key step.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428024030102