The Influence of the Sizes of Nanodiamond Aggregates in Suspensions on the Efficiency of Sorption of 90Y and 177Lu Isotopes for Further Use in Nuclear Medicine

Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for the use in nuclear medicine. In this work, we investigated the influence of the properties of NDs suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of me...

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Veröffentlicht in:	Radiochemistry (New York, N.Y.) N.Y.), 2024-04, Vol.66 (2), p.198-205
Hauptverfasser:	Kazakov, A. G., Babenya, J. S., Ekatova, T. Y., Vinokurov, S. E., Khvorostinin, E. Y., Ushakov, I. A., Zukau, V. V., Stasyuk, E. S., Nesterov, E. A., Sadkin, V. L., Rogov, A. S., Myasoedov, B. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Aqueous solutions Chemistry Chemistry and Materials Science Chemistry/Food Science Diamonds In vivo methods and tests Lutetium isotopes Nanostructure Nuclear Chemistry Nuclear medicine Nuclides Radioisotopes Sorption Yttrium isotopes
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Zusammenfassung:	Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for the use in nuclear medicine. In this work, we investigated the influence of the properties of NDs suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes 90 Y and 177 Lu and determination of conditions for fabricating promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the NDs surface, while the forms of cations of the studied nuclides in the solution do not affect the sorption value.
ISSN:	1066-3622 1608-3288
DOI:	10.1134/S1066362224020097