Nanodiamonds as Lutetium-177 Carriers for Nuclear Medicine

Nanodiamonds as Lutetium-177 Carriers for Nuclear Medicine

The work investigated the sorption of no-carrier-added 177 Lu isolated from neutron-irradiated 176 Yb 2 O 3 , and carrier-added 177 Lu obtained by irradiation of nat Lu 2 O 3 , by commercial and oxidized nanodiamonds (NDs) of various grades from aqueous solutions to identify among them a promising c...

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Veröffentlicht in:Radiochemistry (New York, N.Y.) N.Y.), 2024-04, Vol.66 (2), p.191-197
Hauptverfasser: Kazakov, A. G., Babenya, J. S., Ekatova, T. Y., Vinokurov, S. E., Khvorostinin, E. Y., Ushakov, I. A., Zukau, V. V., Stasyuk, E. S., Nesterov, E. A., Sadkin, V. L., Rogov, A. S., Myasoedov, B. F.
Format: Artikel
Sprache:eng
Schlagworte:
Aqueous solutions
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Diamonds
Lutetium
Lutetium isotopes
Nanostructure
Neutron irradiation
Nuclear Chemistry
Nuclear medicine
Sorbents
Sorption
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Zusammenfassung:The work investigated the sorption of no-carrier-added 177 Lu isolated from neutron-irradiated 176 Yb 2 O 3 , and carrier-added 177 Lu obtained by irradiation of nat Lu 2 O 3 , by commercial and oxidized nanodiamonds (NDs) of various grades from aqueous solutions to identify among them a promising carrier for further research in the field of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP grade (ox-STP); conditions for the fast sorption of lutetium with it in an amount equivalent to 1.2 GBq of no-carrier-added 177 Lu were determined, which corresponds to the activity used in therapy.
ISSN:1066-3622
1608-3288
DOI:10.1134/S1066362224020085