Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals

The aim of this work was to analyze the multi-elemental composition of the extracts of J. nigra husk, with an assessment of the possible influence of their microelements on biochemical, toxicological and radioprotective effects of in rats exposed to radiation from 99m Tc-radiopharmaceuticals. The elements in extract were quantified: microelements (Zn>Al>Se>Cu>Sr>Cr>Ni>Mn>Ba>I>V) and toxic-elements (Pb>Hg>Cd>As). The use of extract in rats showed no clinical evidence of toxicity in terms of biochemical parameters. The results showed significant alteration in the organs accumulation of 99m Tc-radiopharmaceuticals. The results showed that extract of J. nigra husk may act as a potential radioprotector of organ system.