TBHP: A Sustainable Alternative For Carbon‐Oxygen Bond Formation

Over past few decades, synthetic chemists are working tirelessly for the development of environmentally benign and economically competent carbon‐oxygen bond formation processes. Various oxidizing reagents and catalysts are being used to serve this purpose. Among all, t‐butyl hydrogen peroxide (TBHP) has emerged as a greener and economically viable oxygen source, radical initiator and precursor of t‐BuO⋅ and t‐BuOO⋅ radicals. It has been extensively utilized as a reagent for the synthesis of epoxides, ketones, secondary alcohols, heterocyclic rings like benzofurans, isoquinoline and many more. The present review will unfold the recent advancements made in the field of TBHP‐promoted C−O bond formation. TBHP has emerged as a greener and economically viable oxygen source, radical initiator and precursor of t‐BuO⋅ and t‐BuOO⋅ radicals. It is extensively utilized as a reagent for the synthesis of epoxides, ketones, secondary alcohols, heterocyclic rings like benzofurans, isoquinoline and many more. The present review unfolds the recent advancements made in the field of TBHP‐promoted C−O bond formation.