Classification of anti-oxidant proteins using novel physiochemical and conjoint-quad (PCQ) feature composition

The anti-oxidant proteins have a closer relation to disease control. Hence an accurate classification of antioxidant proteins by automated analysis is an essential process for the expansion of drugs for various diseases. Wet-lab experimental approaches are generally expensive and inefficient for the...

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Veröffentlicht in:Multimedia tools and applications 2024-05, Vol.83 (16), p.48831-48857
Hauptverfasser: Alphonse, A. Sherly, Mary, N. Ani Brown
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Sprache:eng
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Zusammenfassung:The anti-oxidant proteins have a closer relation to disease control. Hence an accurate classification of antioxidant proteins by automated analysis is an essential process for the expansion of drugs for various diseases. Wet-lab experimental approaches are generally expensive and inefficient for the identification of anti-oxidant proteins. Novel methodologies like Physiochemical and Conjoint-Quad (PCQ) feature composition using the physio-chemical features combined with moment-based features is proposed in this work for the accurate classification of anti-oxidant proteins. In this proposed work, four techniques namely, proposed PCQ, k-spaced Amino Acid Pairs (CKSAAP), g-gap, and N-gram (N = 3) were applied to create different hybrid features from the anti-oxidant proteins efficiently. The Pearson Kernel-based Supervised Principal Component Analysis (PKSPCA) is proposed for the dimension reduction of the features and effective classification. To evaluate the proposed technique, ten-fold cross-validation and independent test datasets were utilized. On the testing data, the proposed method attained the best performance when compared with the previous techniques. This proposed method achieves 99% accuracy, sensitivity of 98% and specificity of 91% during the classification of the anti-oxidant proteins.
ISSN:1573-7721
1380-7501
1573-7721
DOI:10.1007/s11042-023-17498-w