Cellular‐Scale Matrix Stiffness Gradient at Soft‐Hard Tissue Interfaces Regulates Immunophenotype of Mesenchymal Stem Cells (Adv. Funct. Mater. 18/2024)

Cellular‐Scale Matrix Stiffness Gradient at Soft‐Hard Tissue Interfaces Regulates Immunophenotype of Mesenchymal Stem Cells (Adv. Funct. Mater. 18/2024)

Matrix Stiffness Gradient Humans possess different kinds of soft‐hard tissue interfaces, where the immunophenotype of mesenchymal stem cells (MSCs) can be efficiently modulated by the matrix stiffness gradient existing in these interfaces. In article number 2309676, Yufei Ma, Dandan Pei, Ang Li, Fen...

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Veröffentlicht in:Advanced functional materials 2024-05, Vol.34 (18), p.n/a
Hauptverfasser: Zhang, Hui, Ma, Yufei, Shu, Wenya, Wang, Yijie, Cao, Chunyu, Wan, Wanting, Shi, Nianyuan, Wei, Zhao, Pei, Dandan, Li, Ang, Xu, Feng
Format: Artikel
Sprache:eng
Schlagworte:
front‐rear polarity
immunoregulation
soft‐hard tissue interface
Stem cells
Stiffness
stiffness gradient
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Zusammenfassung:Matrix Stiffness Gradient Humans possess different kinds of soft‐hard tissue interfaces, where the immunophenotype of mesenchymal stem cells (MSCs) can be efficiently modulated by the matrix stiffness gradient existing in these interfaces. In article number 2309676, Yufei Ma, Dandan Pei, Ang Li, Feng Xu, and co‐workers design a two layered hydrogel platform with high and low stiffness gradients, respectively, which can recapitulate the in vivo matrix stiffness gradient and achieve MSC immunoregulation.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202470099