Air pollution-induced missed abortion risk for pregnancies

Fetus death risk reduction is included in the United Nations Sustainable Development Goals. However, little is known about how missed abortion in the first trimester (MAFT) is related to maternal air pollution exposure. We quantify the link between air pollution exposure and MAFT in Beijing, China, a region with severe MAFT and air quality problems. We analyse the records of 255,668 pregnant women from 2009 to 2017 and contrast them with maternal exposure to air pollutants (particulate matter PM 2.5 , SO 2 , O 3 and CO). We adjust for confounding factors such as sociodemographic characteristics, spatial autocorrelation and ambient temperature. We find that, for all four pollutants, an increased risk of MAFT is associated with rises in pollutant concentrations and the adjusted odds ratios (ORs) of these associations increase with higher concentrations. For example, the adjusted OR of MAFT risk for a 10.0 μg m −3 increase in SO 2 exposure is between 1.29 and 1.41 at concentrations of 7.1–19.5 μg m −3 ; it drops to 1.17 below this range and rises to 1.52 above it at higher SO 2 concentrations. This means that the risk increase is not linear but becomes more severe the higher the pollutant concentration. The findings provide evidence linking fetus disease burden and maternal air pollution exposure. A study of over 250,000 pregnant women in Beijing, China, finds that missed abortion is associated with the concentration of four major air pollutants. The association is not linear but becomes stronger with higher concentrations.