Evaluation of kidney disease using e-GFR compared to measured creatinine clearance

Measurement of renal function is required for diagnosis and stratification of kidney disease. Glomerular filtration rate (GFR) is considered as the best overall measure of kidney function for diagnosis and treatment of patients with chronic kidney disease (CKD). Measuring GFR is time consuming and hence eGFR is useful using equations with endogenous markers like serum creatinine (SCr). Therefore, it is of interest to examine the accuracy of creatinine based estimates (CrCl and CG) of GFR among patients. Thus, 60 inpatients (30 men and 30 women) at the GVP hospital, Visakhapatnam, India and 40 controls were enrolled for the study. SCr and 24 hrs urine creatinine are estimated using blood sample and same day 24-hr urine collection. SCr is estimated using the Kinetic Jaffe's method in AUTO ANALYSER for serum and urine analysis. Further, eGFR is calculated using the CG formula using the SCr value. The correlation between measured CrCl derived from 24-hr urine collection and calculated/predicted CrCl using the CG equations is reported. Thus, a positive correlation was observed between measured GFR and e-GFR in case and control groups is documented.