The race to find factors for organelle fission heats up

The mammalian protein MR0H1 is equivalent to the protein encoded by the worm gene hpo-27, and lysosomes look extensively tubular when MR0H1 is removed from mammalian cells. GTP hydrolysis by these enzymes drives a conformational change in the scaffold, causing it to constrict the underlying tubule, which results in fission11. C. elegans embryos that lacked the gene /zpo-27had low survival rates and the few survivors showed notable growth defects and enhanced susceptibility to fungal infections.