A Multifunctional Biosensor via MXene Assisted by Conductive Metal–Organic Framework for Healthcare Monitoring

For real‐time care of metabolic diseases, it is highly demanded to simultaneously monitor metabolite content and diagnose muscle strength in a rapid and convenient way. However, such a biosensor with integrated functions of detecting chemical and biopotential signals at the same time has seldom been reported. In this work, a multifunctional biosensor, integrating the electrochemical detection of uric acid (UA) and glucose (Glu) in sweat, electrophysiological signal acquisition, and electrostimulation therapy, is designed. Hence, an electrophysiological MOF/MXene electrode is fabricated using highly conductive MXene and porous conductive metal–organic framework (c‐MOF, Ni3(HITP)2). Compared with commercial Ag/AgCl electrode, MOF/MXene electrode has lower electrode/skin interface impedance, higher stability and signal‐to‐noise (SNR). By utilizing the high charge storage capacity (CSC) of MOF/MXene electrode, it can realize muscle treatment by electrostimulation. Besides, with abundant active regions of c‐MOF, the electrode exhibits excellent electrochemical performance in detecting sweat metabolites. Multimodal signals detected by such integrated biosensors are wirelessly transmitted to a mobile terminal, showing significant potential on muscle theranostics and daily non‐invasive monitoring. Additionally, they offer timely nutritional guidance for individuals dealing with hyperuricemia or hyperglycemia. A multifunctional biosensor, capable of integrating electrophysiological recording, electrochemical analyzing, and electrostimulation treating, based on porous conductive metal–organic framework and MXene is fabricated. This integrated biosensor achieves the comprehensive diagnosis and treatment of lower limb muscle dysfunction caused by metabolic diseases, which is highly possible for daily healthcare monitoring.