Innentitelbild: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. 12/2024)

Innentitelbild: Discovery and Mechanistic Elucidation of NQO1‐Bioactivatable Small Molecules That Overcome Resistance to Degraders (Angew. Chem. 12/2024)

Multiomics‐driven elucidation of RBS‐10 as a prodrug bioactivated by the enzyme NQO1 is reported by Antoni Riera, Cristina Mayor‐Ruiz et al. in their Research Article (e202316730). RBS‐10 shows preferential cytotoxicity against cancer cells pan‐resistant to degraders.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie 2024-03, Vol.136 (12), p.n/a
Hauptverfasser: Barbosa, Bárbara M. G., Sfyaki, Aikaterini, Rafael, Sergi, José‐Duran, Ferran, Pous, Joan, Sánchez‐Zarzalejo, Carolina, Perez‐Lopez, Carles, Vilanova, Mar, Cigler, Marko, Gay, Marina, Vilaseca, Marta, Winter, Georg E., Riera, Antoni, Mayor‐Ruiz, Cristina
Format: Artikel
Sprache:eng
Schlagworte:
Biocompatibility
Biological activity
Cancer
Cytotoxicity
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Multiomics‐driven elucidation of RBS‐10 as a prodrug bioactivated by the enzyme NQO1 is reported by Antoni Riera, Cristina Mayor‐Ruiz et al. in their Research Article (e202316730). RBS‐10 shows preferential cytotoxicity against cancer cells pan‐resistant to degraders.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202403450