Visible‐Light‐Promoted Difluoromethylation/Cyclization of 1‐Acryloyl‐2‐cyanoindole for Construction of Difluoromethylated Pyrroloindolediones

Visible‐Light‐Promoted Difluoromethylation/Cyclization of 1‐Acryloyl‐2‐cyanoindole for Construction of Difluoromethylated Pyrroloindolediones

A visible‐light‐promoted cascade difluoromethylation/cyclization reaction to access various difluoromethylated pyrrolo[1,2‐a]indolediones was developed using difluoromethyltriphenylphosphonium bromide salt as the difluoromethylating reagent. A possible radical mechanism has been investigated and pro...

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Veröffentlicht in:Advanced synthesis & catalysis 2024-03, Vol.366 (5), p.1158-1164
Hauptverfasser: Qu, Hongzhao, Yuan, Jinwei, Feng, Zhendong, Guo, Na, Yin, Yanli, Yang, Liangru, Xiao, Yongmei, Qu, Lingbo
Format: Artikel
Sprache:eng
Schlagworte:
Electron transfer
Reagents
Single electrons
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Zusammenfassung:A visible‐light‐promoted cascade difluoromethylation/cyclization reaction to access various difluoromethylated pyrrolo[1,2‐a]indolediones was developed using difluoromethyltriphenylphosphonium bromide salt as the difluoromethylating reagent. A possible radical mechanism has been investigated and proven as a single electron transfer (SET) procedure.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202301173