Spectrophotometric determination of gancyclovir drug by combination reaction with NQS as a reagent

1,2-naphthaquinone-4-sulfonate has been utilized as a reagent in the evolution of a quick and accurate spectrophotometric method for the detection of ganciclovir drugs. The process is established on the colored product formation in the basic medium between the (GCV) and the reagent. At 495 nm, the finished product’s absorbance was measured. At 25 1 °C, a reaction is carried out in an alkaline environment (PH = 9.2). The product, which is reddish orange, was made. UV-Visible spectrophotometer investigated further development of response conditions. Using Job’s plot, the reaction’s stoichiometry was taken into account. With a regression coefficient greater than 0.5, the established method followed the calibration curve in the concentration range (0.5 - 350 g.mL-1) (0.9965). The accuracy of the method was evaluated using the % recovery, which was found in the range (%99) and the % relative standard deviation of less than (0.2%). The thresholds for quantification and detection were 0.545 and 1.818 g.mL-1, respectively. A successful investigation was established and validated to analyze the GCV in the tablet matrix using UV/Visible spectrophotometry. The developed inquiry was discovered to be simple and precise, therefore the suggested technique might be applied for quality control investigations in pharmaceutical metrics.