Assessment of oxidant and antioxidant for the patients with diabetic nephropathy in Al-Najaf Province

Background: Diabetic nephropathy is distinguished by albuminuria gradually increases over time and at a later stage of the disorder, end stage renal disease may arise from decrease in estimated glomerular filtration rate. Objective: study aims for assessing levels of oxidant as well as antioxidant and some biochemical parameter for the patients suffering from diabetic nephropathy and individuals with non-diabetic nephropathy that act as control and compare the result. Method: This study is case control and consist of 90 individuals were separated for two groups, 45 with diabetic nephropathy patients and 45 controls for the study from Dialysis and Kidney Transplant Center in both Al-Sadr Teaching Hospital and Al-Najaf Teaching Hospital. Assessed levels of oxidant and antioxidant for patients and controls by using Spectrophotometric Techniques. Results: findings revealed significant differences between concentration of Total Antioxidants Capacity "(TAC)" and Total Oxidant Status "(TOS)" in diabetic nephropathy and control groups, TOS levels in control group 0.171± 0.01) and in the diabetic nephropathy group (0.325±0.07), While TAC levels in control group (20.33±2.67) and in diabetic nephropathy group (14.78±2.27) and p-value for TOS and TAC in patients and controls (0.001). Conclusion: study showed that decreased levels of Total Antioxidants Capacity (TAC), estimated glomerular filtration rate (eGFR), calcium ion in diabetic nephropathy patients with increased levels of body mass index (BMI), potassium ion, fasting blood sugar (FBS), proteinuria, serum creatinine and blood urea which increases the progression of diabetic nephropathy and other metabolic diseases by inducing oxidative stress.