On‐Chip Reconstitution of Uniformly Shear‐Sensing 3D Matrix‐Embedded Multicellular Blood Microvessel (Adv. Funct. Mater. 10/2024)

Organs‐on‐Chips In article number 2304630, Kambez H. Benam and co‐workers present the design, optimization, and validation of a robust and highly reproducible methodology for constructing centimeters‐long cross‐sectionally rounded, extracellular matrix (ECM)‐embedded, multicellular microvasculature (MV) in an Organ‐on‐a‐Chip device – a platform named “ECM MV‐Chip”. This living system allows culture of primary human‐derived, organ‐specific vascular endothelial cells and stromal cells, and fine control of ECM mechanical properties and composition.