Ring‐Opening Intramolecular Arylation of 1,2‐Disubtituted Epoxides with Tuneable Stereoselectivity

Ring‐Opening Intramolecular Arylation of 1,2‐Disubtituted Epoxides with Tuneable Stereoselectivity

A method of stereodivergent intramolecular ring‐opening arylation of amine‐tethered epoxides to 3,4‐disubstituted tetrahydroquinolines has been developed. The tuneable good stereoselectivity was attained by changing the catalyst from titanocene(III) catalyst to Lewis‐acidic zinc catalyst. A method o...

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Veröffentlicht in:European journal of organic chemistry 2024-03, Vol.27 (9), p.n/a
Hauptverfasser: Zhao, Cong‐Cong, Shen, Chaoren, Wang, Bin, Rong, Liangce, Dong, Kaiwu
Format: Artikel
Sprache:eng
Schlagworte:
arylation
Catalysts
epoxide
Lewis acid
Stereoselectivity
titanocene
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Zusammenfassung:A method of stereodivergent intramolecular ring‐opening arylation of amine‐tethered epoxides to 3,4‐disubstituted tetrahydroquinolines has been developed. The tuneable good stereoselectivity was attained by changing the catalyst from titanocene(III) catalyst to Lewis‐acidic zinc catalyst. A method of stereodivergent intramolecular ring‐opening arylation of amine‐tethered epoxides to 3,4‐disubstituted tetrahydroquinolines has been developed. The tuneable good stereoselectivity was attained by switching the catalyst from titanocene(III) to Lewis–acidic zinc catalyst.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202301271