Front Cover: Assessing Lanthanide‐Dependent Methanol Dehydrogenase Activity: The Assay Matters (ChemBioChem 5/2024)

We investigate the enzyme activity of eight lanthanide‐dependent methanol dehydrogenases through two different activity assays. Contrasting trends emerge from the widely used artificial dye‐coupled assay (left) versus the protein coupled assay (right), underscoring the significance of why the choice of assay matters. The cover features a well plate illustrating results from both assays with a maze overlay distinguishing the misleading from the “straightforward” assay. (designed by Sophie Marie Gutenthaler‐Tietze). More information can be found in the Research Article by L. J. Daumann et al.