Three-component reaction of Δ1-pyrrolines, electron-deficient acetylenes, and NH-pyrroles. Synthesis of 2-(pyrrolyl)pyrrolidinyl acrylonitriles and enones

Three-component reaction of Δ1-pyrrolines, electron-deficient acetylenes, and NH-pyrroles. Synthesis of 2-(pyrrolyl)pyrrolidinyl acrylonitriles and enones

Addition of NH-pyrroles acting as electrophiles to zwitterionic adducts of Δ 1 -pyrrolines and electron-deficient acetylenes (20–25 °C, 4–30 h) gave 2-(pyrrol-1-yl)pyrrolidin-1-ylacrylonitriles and 2-(pyrrol-1-yl)pyrrolidin-1-ylenones in 18–48% yields.

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Veröffentlicht in:Russian chemical bulletin 2024, Vol.73 (1), p.141-145
Hauptverfasser: Oparina, L. A., Kolyvanov, N. A., Ushakov, I. A., Trofimov, B. A.
Format: Artikel
Sprache:eng
Schlagworte:
Acrylonitriles
Adducts
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
Pyrroles
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Zusammenfassung:Addition of NH-pyrroles acting as electrophiles to zwitterionic adducts of Δ 1 -pyrrolines and electron-deficient acetylenes (20–25 °C, 4–30 h) gave 2-(pyrrol-1-yl)pyrrolidin-1-ylacrylonitriles and 2-(pyrrol-1-yl)pyrrolidin-1-ylenones in 18–48% yields.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-024-4125-x