Left Ventricular Myocardial Performance in Normotensive Offspring of Hypertensive Parents

Introduction Early alterations in the cardiovascular system have been described in offspring of hypertensive parents, but with conflicting results. Aim To evaluate the influence of genetic predisposition to hypertension on left ventricular (LV) geometry and function, 30 normotensive male offspring o...

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Veröffentlicht in:	High blood pressure & cardiovascular prevention 2019-12, Vol.26 (6), p.501-508
Hauptverfasser:	Pattoneri, Paolo, Ceriati, Roberta, Belforti, Vittoriano, Pelà, Giovanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Pressure Cardiology Case-Control Studies Child of Impaired Parents Doppler effect Echocardiography, Doppler Families & family life Humans Hypertension Hypertension - complications Hypertension - diagnosis Hypertension - genetics Hypertension - physiopathology Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - genetics Hypertrophy, Left Ventricular - physiopathology Male Medicine Medicine & Public Health Original Article Parents & parenting Pharmacotherapy Regression analysis Risk Assessment Risk Factors Ultrasonic imaging Variance analysis Velocity Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - genetics Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left Ventricular Remodeling Young Adult
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Zusammenfassung:	Introduction Early alterations in the cardiovascular system have been described in offspring of hypertensive parents, but with conflicting results. Aim To evaluate the influence of genetic predisposition to hypertension on left ventricular (LV) geometry and function, 30 normotensive male offspring of hypertensive parents (EH+) and 30 matched offspring of normotensive families (EH−), were studied. Methods All subjects underwent office and 24-h ambulatory blood pressure monitoring (ABPM), conventional and Tissue Doppler Echocardiography (TDE), including assessment of myocardial performance index (MPI). Results EH+ showed an increase in office BP with statistical significance in diastolic BP (84 ± 7 vs 73 ± 6 mmHg; p
ISSN:	1120-9879 1179-1985
DOI:	10.1007/s40292-019-00343-3