Host miRNA Polymorphisms in Viral-induced Hepatocellular Carcinoma Outcomes: A Common Disease Underlying Liver Transplantation

The search was directed in PubMed, Web of Science, and Scopus databases that resulted in 33 related original articles and 8 reviews that used for finding any missing reports. [...]in this review it is tried to discuss the importance and relation of SNPs in host miRNAs during viral induced HCC complications. Despite the effectiveness of LT for HCC, due to the scarcity of organs, the careful selection and management of patients who can derive significant survival benefits from LT remains a fundamental concern. [...]limiting tumor recurrence after LT is a way to optimize this scarce resource p]. RESULTS miRNAs' General Features and the SNPs Affecting the Biogenesis and Action of miRNAs miRNAs are small non-coding RNAs that are 18 to 25 nucleotide long and regulate many different biological processes including substantial roles in viral infections and cancers pathogenesis. [...]here we first discuss the biogenesis pathway of miRNA production and then focus on the mutations that might affect this process. miRNAs Biogenesis miRNAs are well-known for their ability in gene expression modifications post-transcription in almost all of the eukaryotes such as human beings. [...]in human beings commonly miRNAs are transcribed by the action of RNA Polli (polymerase II) in the nucleus that produce pri-miRNA molecules, a long RNA transcript composed of 500-3,000 bases (see Fig. 1).