Front Cover: New Indole‐6‐Carboxylic Acid Derivatives as Multi‐Target Antiproliferative Agents: Synthesis, in Silico Studies, and Cytotoxicity Evaluation (Chem. Biodiversity 2/2024)

Front Cover. EGFR and VEGFR‐2 are commonly overexpressed in cancers making them attractive targets for cancer therapy. Hydrazone and oxadiazole derivatives of indole‐6‐carboxylic acid, targeting EGFR and VEGFR‐2, respectively, were synthesized to improve lack of selectivity of chemotherapeutic agent...

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Veröffentlicht in:Chemistry & biodiversity 2024-02, Vol.21 (2), p.n/a
Hauptverfasser: Allawi, Mustafa M., Mahmood, Ammar A. Razzak, Tahtamouni, Lubna H., AlSakhen, Mai F., Kanaan, Sana I., Saleh, Khaled M., Yasin, Salem R.
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Sprache:eng
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Zusammenfassung:Front Cover. EGFR and VEGFR‐2 are commonly overexpressed in cancers making them attractive targets for cancer therapy. Hydrazone and oxadiazole derivatives of indole‐6‐carboxylic acid, targeting EGFR and VEGFR‐2, respectively, were synthesized to improve lack of selectivity of chemotherapeutic agents. The new derivatives with antiproliferation activity through the induction of the extrinsic apoptosis pathway were presented by M. Allawi et al. in their research article at 10.1002/cbdv.202301892.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202400233