Development of Approaches for Obtaining Fluorine-Containing Derivatives of Boronated Amidines Based on the closo-Dodecaborate Anion

Development of Approaches for Obtaining Fluorine-Containing Derivatives of Boronated Amidines Based on the closo-Dodecaborate Anion

The reactivity of model amidines with general structure (NBu 4 )[B 12 H 11 NHC(CH 3 )HNCH(CH 2 OTos) 2 ] under nucleophilic fluorination conditions has been investigated in the study. The obtained products have been characterized using multinuclear NMR and IR spectroscopies, RP-HPLC, and high-resolu...

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Veröffentlicht in:Russian journal of inorganic chemistry 2023-12, Vol.68 (14), p.1923-1928
Hauptverfasser: Ryabchikova, M. N., Neumolotov, N. K., Nelyubin, A. V., Selivanov, N. A., Klyukin, I. N., Bykov, A. Yu, Zhdanov, A. P., Zhizhin, K. Yu, Kuznetsov, N. T.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Fluorination
Fluorine
Inorganic Chemistry
Mass spectrometry
NMR
Nuclear magnetic resonance
Synthesis and Properties of Inorganic Compounds
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Zusammenfassung:The reactivity of model amidines with general structure (NBu 4 )[B 12 H 11 NHC(CH 3 )HNCH(CH 2 OTos) 2 ] under nucleophilic fluorination conditions has been investigated in the study. The obtained products have been characterized using multinuclear NMR and IR spectroscopies, RP-HPLC, and high-resolution mass spectrometry. The results obtained can be applied in the synthesis of similar derivatives containing 18 F atoms for studying the pharmacokinetic parameters of BNCT agents using the PET method.
ISSN:0036-0236
1531-8613
DOI:10.1134/S0036023623603252