ASSESSMENT OF SUB-ACUTE ORAL ADMINISTRATION OF AN AQUEOUS EXTRACT OF Drimia Maritima's BULB AND LEAVES ON LIVER AND KIDNEY FUNCTION IN ALBINO WISTAR RATS

Based on the numerous medicinal benefits of the plantDrimia maritima (L.) Baker (Asparagaceae) and its use in the environment, this study examined the risk of this use on non-target species by examining the phytochemical and toxicological profile of the aqueous extract of D. maritima bulb and leaves on the liver and kidney function ofWistar rats. Seven groups of rats (n = 6) were utilized for subacute studies, including a control, three doses of an aqueous extract of D. maritima bulb (DBAE), and three doses of an aqueous extract of D. maritima leaves (DLAE), each at a dose of98, 49, and 24.5 mg/ kg. The findings showed that both plant extracts include a large amount of phenolic chemicals, which provide them great antioxidant capability. Additionally, only the high oral dosage of DBAE showed a modest rise in hepatic and renal enzymes, even though the antioxidant enzyme levels (GST, GPx, and GSH) in the liver and kidney remained steady and hematological parameters did not change. However, none of the measures under study significantly changed because of the three DLAE dosages involved. The antioxidant status of both D. maritima extracts is raised. After subacute administration at levels below 98 mg/ kg body weight, DBAE was mostly non-toxic. But at the studied levels, DLAE was safe.