2212 Pretreatment peripheral immune cell ratios as prognostic biomarkers in glioma patients

BackgroundIn the glioma microenvironment, elevated immune cell ratios are posited to reflect systemic response to malignancy. Given the dearth in clinically significant molecular markers to predict prognosis, there is potential for immune cell ratios to serve as low-cost and readily available prognostic markers.ObjectivesThis study evaluated the ability for pretreatment peripheral immune cell ratios (Neutrophil-to-Lymphocyte Ratio, NLR, and Monocyte-to-Lymphocyte Ratio, MLR) to predict overall survival (OS) and modified Rankin Scale (mRS) at admission, 6 months and 12 months post-diagnosis. It also explored relationships between immune cell ratios and clinicopathological parameters (tumour location, tumour size, tumour grade, IDH-1 mutation, MGMT promoter methylation status).MethodsPretreatment NLR and MLR were analysed retrospectively in 64 glioma patients from Royal Melbourne Hospital. OS was evaluated with the Kaplan-Meier method. Prognostic factors for OS and mRS were evaluated with univariate and multivariable regression analyses.ResultsHigher pretreatment NLR (>4.7), compared to lower pretreatment NLR (≤4.7), predicted higher mean admission mRS (p