Neurohumoral changes in rats of different age groups on the background of injection of cryopreserved cord blood nucleated cells

Neurohumoral changes in rats of different age groups on the background of injection of cryopreserved cord blood nucleated cells

The application of a cryopreserved preparation of UCB NCs to rats was accompanied by enhanced activity of all neurohumoral regulation elements of heart rate, although the absolute parameters in 18- and 24-month-old animals did not reach values similar to those in groups of younger age. We also notic...

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Veröffentlicht in:Advances in gerontology 2016-10, Vol.6 (4), p.304-310
Hauptverfasser: Martynova, Yu. V., Babiychuk, V. G., Sirotenko, L. A., Malova, N. G., Babiychuk, L. V.
Format: Artikel
Sprache:eng
Schlagworte:
Age groups
Aging
Electrocardiography
Geriatrics
Geriatrics/Gerontology
Gerontology
Heart rate
Hormone replacement therapy
Laboratory animals
Medicine
Medicine & Public Health
Nervous system
Stem cells
Thyroid gland
Umbilical cord
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Zusammenfassung:The application of a cryopreserved preparation of UCB NCs to rats was accompanied by enhanced activity of all neurohumoral regulation elements of heart rate, although the absolute parameters in 18- and 24-month-old animals did not reach values similar to those in groups of younger age. We also noticed an increase of the thyroid hormone concentration in the blood serum of the old rats. The concentration decreased with age. In addition, it was shown that the injection of UCB NCs during the animal’s life cycle (every 6 months) made it possible to maintain a functional state of the autonomous nervous system at a “young” physiological level.
ISSN:2079-0570
2079-0589
DOI:10.1134/S2079057016040093