A correspondence between the models of Hodgkin-Huxley and FitzHugh-Nagumo revisited
. We present the discussion on the possibility to scale the classical dimensionless FitzHugh-Nagumo model of neuronal self-sustained oscillations to the range of variables corresponding to the results, which are provided by the biophysically relevant reduced two-dimensional Hodgkin-Huxley equations...
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Veröffentlicht in: | European physical journal plus 2016-11, Vol.131 (11), p.411, Article 411 |
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Format: | Artikel |
Sprache: | eng |
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We present the discussion on the possibility to scale the classical dimensionless FitzHugh-Nagumo model of neuronal self-sustained oscillations to the range of variables corresponding to the results, which are provided by the biophysically relevant reduced two-dimensional Hodgkin-Huxley equations (the Rinzel model). It is shown that there exists a relatively simple choice of affine transformation, which results in time-dependent solutions, which reproduce with a high accuracy the time course of the recovery variable and the sharp onsets (intervals of fast motions on a phase trajectories) of the voltage spikes. As for the latter, the reasons for unavoidable difference are discussed as well as a necessity of taking into account applied current values during such a scaling procedure. |
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ISSN: | 2190-5444 2190-5444 |
DOI: | 10.1140/epjp/i2016-16411-1 |