Analysis of the associations of polymorphic loci in TP53 and NFKB1 genes with human age and longevity
The TP53 and NFKB1 genes are of considerable interest as human aging and longevity candidate genes. A TP 53 gene R 72 P ( rs 1042522) polymorphism and NFKB1 gene 2592 + 58 T > A ( rs 4648110) polymorphism allele and genotype frequencies have been estimated in the groups of men and women aged betw...
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| Veröffentlicht in: | Advances in gerontology 2012-04, Vol.2 (2), p.120-126 |
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| creator | Mustafina, O. E. Nasibullin, T. R. Erdman, V. V. Tuktarova, I. A. |
| description | The
TP53
and
NFKB1
genes are of considerable interest as human aging and longevity candidate genes. A
TP
53 gene
R
72
P
(
rs
1042522) polymorphism and
NFKB1
gene 2592 + 58
T
>
A
(
rs
4648110) polymorphism allele and genotype frequencies have been estimated in the groups of men and women aged between 21–109 years. No statistically significant differences in genotype and allele frequencies have been detected between the long livers, elderly, and other age groups. The results of logistic regression analysis suggest that
TP
53 gene
R
72
P
polymorphism and
NFKB1
gene 2592 + 58
T
>
A
polymorphism are associated with age mainly during the elderly and senile age periods and that
TP
53*
R
/*
R
and
NFKB1
*
A
/*
A
genotypes carriers have relatively higher chances to reach age of 80–90
TP
53 and
NFKB1
genes are also likely to be considered genes are frailty genes rather than longevity genes. |
| doi_str_mv | 10.1134/S2079057012020129 |
| format | Article |
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TP53
and
NFKB1
genes are of considerable interest as human aging and longevity candidate genes. A
TP
53 gene
R
72
P
(
rs
1042522) polymorphism and
NFKB1
gene 2592 + 58
T
>
A
(
rs
4648110) polymorphism allele and genotype frequencies have been estimated in the groups of men and women aged between 21–109 years. No statistically significant differences in genotype and allele frequencies have been detected between the long livers, elderly, and other age groups. The results of logistic regression analysis suggest that
TP
53 gene
R
72
P
polymorphism and
NFKB1
gene 2592 + 58
T
>
A
polymorphism are associated with age mainly during the elderly and senile age periods and that
TP
53*
R
/*
R
and
NFKB1
*
A
/*
A
genotypes carriers have relatively higher chances to reach age of 80–90
TP
53 and
NFKB1
genes are also likely to be considered genes are frailty genes rather than longevity genes.</description><identifier>ISSN: 2079-0570</identifier><identifier>EISSN: 2079-0589</identifier><identifier>DOI: 10.1134/S2079057012020129</identifier><language>eng</language><publisher>Dordrecht: SP MAIK Nauka/Interperiodica</publisher><subject>Age groups ; Aging ; Apoptosis ; Cancer ; Cell cycle ; Cytokines ; Genes ; Genomes ; Geriatrics/Gerontology ; Gerontology ; Kinases ; Medicine ; Medicine & Public Health ; Polymorphism ; Proteins ; Regression analysis ; Transcription factors ; Women</subject><ispartof>Advances in gerontology, 2012-04, Vol.2 (2), p.120-126</ispartof><rights>Pleiades Publishing, Ltd. 2012</rights><rights>Pleiades Publishing, Ltd. 2012.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2319-b4decbfd48ac97bdb3d31518bc6f5e9924c6463d19a4e9b471a75817a147ab903</citedby><cites>FETCH-LOGICAL-c2319-b4decbfd48ac97bdb3d31518bc6f5e9924c6463d19a4e9b471a75817a147ab903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S2079057012020129$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2919608913?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,27924,27925,33530,33744,41488,42557,43659,43805,51319,64385,64389,72469</link.rule.ids></links><search><creatorcontrib>Mustafina, O. E.</creatorcontrib><creatorcontrib>Nasibullin, T. R.</creatorcontrib><creatorcontrib>Erdman, V. V.</creatorcontrib><creatorcontrib>Tuktarova, I. A.</creatorcontrib><title>Analysis of the associations of polymorphic loci in TP53 and NFKB1 genes with human age and longevity</title><title>Advances in gerontology</title><addtitle>Adv Gerontol</addtitle><description>The
TP53
and
NFKB1
genes are of considerable interest as human aging and longevity candidate genes. A
TP
53 gene
R
72
P
(
rs
1042522) polymorphism and
NFKB1
gene 2592 + 58
T
>
A
(
rs
4648110) polymorphism allele and genotype frequencies have been estimated in the groups of men and women aged between 21–109 years. No statistically significant differences in genotype and allele frequencies have been detected between the long livers, elderly, and other age groups. The results of logistic regression analysis suggest that
TP
53 gene
R
72
P
polymorphism and
NFKB1
gene 2592 + 58
T
>
A
polymorphism are associated with age mainly during the elderly and senile age periods and that
TP
53*
R
/*
R
and
NFKB1
*
A
/*
A
genotypes carriers have relatively higher chances to reach age of 80–90
TP
53 and
NFKB1
genes are also likely to be considered genes are frailty genes rather than longevity genes.</description><subject>Age groups</subject><subject>Aging</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Cytokines</subject><subject>Genes</subject><subject>Genomes</subject><subject>Geriatrics/Gerontology</subject><subject>Gerontology</subject><subject>Kinases</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Polymorphism</subject><subject>Proteins</subject><subject>Regression analysis</subject><subject>Transcription factors</subject><subject>Women</subject><issn>2079-0570</issn><issn>2079-0589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1UEFOwzAQtBBIVNAHcLPEueC1nTg-looCogIkyjlyHKdxlcbBTkH5PW6L4IDYw-5qdmakWYQugFwBMH79SomQJBEEKKGxySM02kETkmTy-GcX5BSNQ1iTWAmhgpARMtNWNUOwAbsK97XBKgSnreqta_dY55ph43xXW42beMG2xcuXhGHVlvhp_ngDeGVaE_Cn7WtcbzeqxWpl9ufGtSvzYfvhHJ1Uqglm_D3P0Nv8djm7nyye7x5m08VEUwZyUvDS6KIqeaa0FEVZsJJBAlmh0yoxUlKuU56yEqTiRhZcgBJJBkIBF6qQhJ2hy4Nv59371oQ-X7utjwlDTiXIlGQSWGTBgaW9C8GbKu-83Sg_5EDy3UPzPw-NGnrQhMiNqfyv8_-iL1jVdfY</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Mustafina, O. E.</creator><creator>Nasibullin, T. R.</creator><creator>Erdman, V. V.</creator><creator>Tuktarova, I. A.</creator><general>SP MAIK Nauka/Interperiodica</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>201204</creationdate><title>Analysis of the associations of polymorphic loci in TP53 and NFKB1 genes with human age and longevity</title><author>Mustafina, O. E. ; Nasibullin, T. R. ; Erdman, V. V. ; Tuktarova, I. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2319-b4decbfd48ac97bdb3d31518bc6f5e9924c6463d19a4e9b471a75817a147ab903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age groups</topic><topic>Aging</topic><topic>Apoptosis</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Cytokines</topic><topic>Genes</topic><topic>Genomes</topic><topic>Geriatrics/Gerontology</topic><topic>Gerontology</topic><topic>Kinases</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Polymorphism</topic><topic>Proteins</topic><topic>Regression analysis</topic><topic>Transcription factors</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mustafina, O. E.</creatorcontrib><creatorcontrib>Nasibullin, T. R.</creatorcontrib><creatorcontrib>Erdman, V. V.</creatorcontrib><creatorcontrib>Tuktarova, I. A.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Advances in gerontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mustafina, O. E.</au><au>Nasibullin, T. R.</au><au>Erdman, V. V.</au><au>Tuktarova, I. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the associations of polymorphic loci in TP53 and NFKB1 genes with human age and longevity</atitle><jtitle>Advances in gerontology</jtitle><stitle>Adv Gerontol</stitle><date>2012-04</date><risdate>2012</risdate><volume>2</volume><issue>2</issue><spage>120</spage><epage>126</epage><pages>120-126</pages><issn>2079-0570</issn><eissn>2079-0589</eissn><abstract>The
TP53
and
NFKB1
genes are of considerable interest as human aging and longevity candidate genes. A
TP
53 gene
R
72
P
(
rs
1042522) polymorphism and
NFKB1
gene 2592 + 58
T
>
A
(
rs
4648110) polymorphism allele and genotype frequencies have been estimated in the groups of men and women aged between 21–109 years. No statistically significant differences in genotype and allele frequencies have been detected between the long livers, elderly, and other age groups. The results of logistic regression analysis suggest that
TP
53 gene
R
72
P
polymorphism and
NFKB1
gene 2592 + 58
T
>
A
polymorphism are associated with age mainly during the elderly and senile age periods and that
TP
53*
R
/*
R
and
NFKB1
*
A
/*
A
genotypes carriers have relatively higher chances to reach age of 80–90
TP
53 and
NFKB1
genes are also likely to be considered genes are frailty genes rather than longevity genes.</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S2079057012020129</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Advances in gerontology, 2012-04, Vol.2 (2), p.120-126 |
| issn | 2079-0570 2079-0589 |
| language | eng |
| recordid | cdi_proquest_journals_2919608913 |
| source | ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Age groups Aging Apoptosis Cancer Cell cycle Cytokines Genes Genomes Geriatrics/Gerontology Gerontology Kinases Medicine Medicine & Public Health Polymorphism Proteins Regression analysis Transcription factors Women |
| title | Analysis of the associations of polymorphic loci in TP53 and NFKB1 genes with human age and longevity |
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