Analysis of the associations of polymorphic loci in TP53 and NFKB1 genes with human age and longevity

The TP53 and NFKB1 genes are of considerable interest as human aging and longevity candidate genes. A TP 53 gene R 72 P ( rs 1042522) polymorphism and NFKB1 gene 2592 + 58 T > A ( rs 4648110) polymorphism allele and genotype frequencies have been estimated in the groups of men and women aged betw...

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Veröffentlicht in:Advances in gerontology 2012-04, Vol.2 (2), p.120-126
Hauptverfasser: Mustafina, O. E., Nasibullin, T. R., Erdman, V. V., Tuktarova, I. A.
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Sprache:eng
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Zusammenfassung:The TP53 and NFKB1 genes are of considerable interest as human aging and longevity candidate genes. A TP 53 gene R 72 P ( rs 1042522) polymorphism and NFKB1 gene 2592 + 58 T > A ( rs 4648110) polymorphism allele and genotype frequencies have been estimated in the groups of men and women aged between 21–109 years. No statistically significant differences in genotype and allele frequencies have been detected between the long livers, elderly, and other age groups. The results of logistic regression analysis suggest that TP 53 gene R 72 P polymorphism and NFKB1 gene 2592 + 58 T > A polymorphism are associated with age mainly during the elderly and senile age periods and that TP 53* R /* R and NFKB1 * A /* A genotypes carriers have relatively higher chances to reach age of 80–90 TP 53 and NFKB1 genes are also likely to be considered genes are frailty genes rather than longevity genes.
ISSN:2079-0570
2079-0589
DOI:10.1134/S2079057012020129