Stimulating Effect of the Water-Soluble Fraction from Brown Algae Fucus vesiculosus Extract on Cell Proliferation in the Tissue Culture of Young and Old Rats

The influence of the F-55 water-soluble fraction of brown algae extract Fucus vesiculosus on the development of organotypic tissue culture of various origins from three germ layers in young and old rats was studied. The F-55 preparation has a stimulating effect on the processes of cell proliferation in tissues of ecto-, ento- and mesodermal genesis (cerebral cortex, myocardium, spleen, and liver) by regulating the processes of cell proliferation and apoptosis. The revealed strengthening of regeneration processes in explants from both young and old rats under the influence of the F-55 preparation in ultra-low concentrations of 10–100 ng/mL can be used to produce new, medicinal, cytoprotective substances that allow the enhancement of cell regeneration in various tissues under pathological conditions, including those associated with age.