Controllable Adaptive Molybdate‐Oligosaccharide Nanoparticles Regulate M2 Macrophage Mitochondrial Function and Promote Angiogenesis via PI3K/HIF‐1α/VEGF Pathway to Accelerate Diabetic Wound Healing (Adv. Healthcare Mater. 3/2024)
Molybdate‐Oligosaccharide Nanosystem The powerful molybdate‐oligosaccharide nanosystem (CMO) exhibit pH‐responsive release Mo2+ and oligosaccharide to enhance mitochondrial function and facilitate the transition of macrophages from M1 to M2 phenotype. In article 2302256, Xiuhong Huang, Shaohong Huan...
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| Veröffentlicht in: | Advanced healthcare materials 2024-01, Vol.13 (3), p.n/a |
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| creator | Huang, Xiuhong Zheng, Liqin Zhou, Yueshan Hu, Shaonan Ning, Wancheng Li, Simin Lin, Ziling Huang, Shaohong |
| description | Molybdate‐Oligosaccharide Nanosystem
The powerful molybdate‐oligosaccharide nanosystem (CMO) exhibit pH‐responsive release Mo2+ and oligosaccharide to enhance mitochondrial function and facilitate the transition of macrophages from M1 to M2 phenotype. In article 2302256, Xiuhong Huang, Shaohong Huang, and co‐workers show that within an anti‐inflammatory microenvironment, CMO promote angiogenesis through activation of the PI3K/HIF‐1α/VEGF pathway. Such a pH‐responsive nanosystem with immunomodulatory properties and angiogenesis‐ and mitochondrial‐promotion capacity presents a promising potential for diabetic wounds repair. |
| doi_str_mv | 10.1002/adhm.202470018 |
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The powerful molybdate‐oligosaccharide nanosystem (CMO) exhibit pH‐responsive release Mo2+ and oligosaccharide to enhance mitochondrial function and facilitate the transition of macrophages from M1 to M2 phenotype. In article 2302256, Xiuhong Huang, Shaohong Huang, and co‐workers show that within an anti‐inflammatory microenvironment, CMO promote angiogenesis through activation of the PI3K/HIF‐1α/VEGF pathway. Such a pH‐responsive nanosystem with immunomodulatory properties and angiogenesis‐ and mitochondrial‐promotion capacity presents a promising potential for diabetic wounds repair.</description><identifier>ISSN: 2192-2640</identifier><identifier>EISSN: 2192-2659</identifier><identifier>DOI: 10.1002/adhm.202470018</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>1-Phosphatidylinositol 3-kinase ; Angiogenesis ; Controllability ; Diabetes mellitus ; Immunomodulation ; Inflammation ; Macrophages ; Mitochondria ; Molybdate ; Nanoparticles ; Oligosaccharides ; Phenotypes ; Vascular endothelial growth factor ; Wound healing</subject><ispartof>Advanced healthcare materials, 2024-01, Vol.13 (3), p.n/a</ispartof><rights>2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadhm.202470018$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadhm.202470018$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Huang, Xiuhong</creatorcontrib><creatorcontrib>Zheng, Liqin</creatorcontrib><creatorcontrib>Zhou, Yueshan</creatorcontrib><creatorcontrib>Hu, Shaonan</creatorcontrib><creatorcontrib>Ning, Wancheng</creatorcontrib><creatorcontrib>Li, Simin</creatorcontrib><creatorcontrib>Lin, Ziling</creatorcontrib><creatorcontrib>Huang, Shaohong</creatorcontrib><title>Controllable Adaptive Molybdate‐Oligosaccharide Nanoparticles Regulate M2 Macrophage Mitochondrial Function and Promote Angiogenesis via PI3K/HIF‐1α/VEGF Pathway to Accelerate Diabetic Wound Healing (Adv. Healthcare Mater. 3/2024)</title><title>Advanced healthcare materials</title><description>Molybdate‐Oligosaccharide Nanosystem
The powerful molybdate‐oligosaccharide nanosystem (CMO) exhibit pH‐responsive release Mo2+ and oligosaccharide to enhance mitochondrial function and facilitate the transition of macrophages from M1 to M2 phenotype. In article 2302256, Xiuhong Huang, Shaohong Huang, and co‐workers show that within an anti‐inflammatory microenvironment, CMO promote angiogenesis through activation of the PI3K/HIF‐1α/VEGF pathway. Such a pH‐responsive nanosystem with immunomodulatory properties and angiogenesis‐ and mitochondrial‐promotion capacity presents a promising potential for diabetic wounds repair.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Angiogenesis</subject><subject>Controllability</subject><subject>Diabetes mellitus</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Macrophages</subject><subject>Mitochondria</subject><subject>Molybdate</subject><subject>Nanoparticles</subject><subject>Oligosaccharides</subject><subject>Phenotypes</subject><subject>Vascular endothelial growth factor</subject><subject>Wound healing</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU1u2zAQhYWiBRqk2XZNoJt2YZmk_qil4MSxkbgxiv4shRFJSQxoUiUlB971CL1KL5JDdNtLlK6LdFluhgN8b95gXhS9JjgmGNM5iH4XU0zTAmPCnkVnlJR0RvOsfP70T_HL6ML7exxenpGckbPo18Ka0VmtodESVQKGUe0l2lh9aASM8ue373daddYD5z04JSR6D8YO4EbFtfTog-wmHUC0oWgD3Nmhhy50arS8t0Y4BRotJ8NHZQ0CI9DW2Z0Ngsp0ynbSSK882itA23VyM1-tl8GTPP6Yf766XqItjP0DHNBoUcW51NIdvS4VNDIsgL7YKUxcSdDKdOhtJfbxn27sObiwRYBdjJL58TLvXkUvWtBeXvyt59Gn5dXHxWp2e3e9XlS3M06ygs0K0jDBscSZYKLM0iQjBDNSZJQzniQFS0raACOtAJI2vMjbtJUZbhhLaZrmMjmP3pzmDs5-naQf63s7ORMsa1oSVpA8TWig4hMVbua9k209OLUDd6gJro-Z1sdM66dMg6A8CR6Ulof_0HV1udr80_4GuZKpCA</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Huang, Xiuhong</creator><creator>Zheng, Liqin</creator><creator>Zhou, Yueshan</creator><creator>Hu, Shaonan</creator><creator>Ning, Wancheng</creator><creator>Li, Simin</creator><creator>Lin, Ziling</creator><creator>Huang, Shaohong</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T5</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7TO</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope></search><sort><creationdate>20240101</creationdate><title>Controllable Adaptive Molybdate‐Oligosaccharide Nanoparticles Regulate M2 Macrophage Mitochondrial Function and Promote Angiogenesis via PI3K/HIF‐1α/VEGF Pathway to Accelerate Diabetic Wound Healing (Adv. 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Healthcare Mater. 3/2024)</atitle><jtitle>Advanced healthcare materials</jtitle><date>2024-01-01</date><risdate>2024</risdate><volume>13</volume><issue>3</issue><epage>n/a</epage><issn>2192-2640</issn><eissn>2192-2659</eissn><abstract>Molybdate‐Oligosaccharide Nanosystem
The powerful molybdate‐oligosaccharide nanosystem (CMO) exhibit pH‐responsive release Mo2+ and oligosaccharide to enhance mitochondrial function and facilitate the transition of macrophages from M1 to M2 phenotype. In article 2302256, Xiuhong Huang, Shaohong Huang, and co‐workers show that within an anti‐inflammatory microenvironment, CMO promote angiogenesis through activation of the PI3K/HIF‐1α/VEGF pathway. Such a pH‐responsive nanosystem with immunomodulatory properties and angiogenesis‐ and mitochondrial‐promotion capacity presents a promising potential for diabetic wounds repair.</abstract><cop>Weinheim</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/adhm.202470018</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 1-Phosphatidylinositol 3-kinase Angiogenesis Controllability Diabetes mellitus Immunomodulation Inflammation Macrophages Mitochondria Molybdate Nanoparticles Oligosaccharides Phenotypes Vascular endothelial growth factor Wound healing |
| title | Controllable Adaptive Molybdate‐Oligosaccharide Nanoparticles Regulate M2 Macrophage Mitochondrial Function and Promote Angiogenesis via PI3K/HIF‐1α/VEGF Pathway to Accelerate Diabetic Wound Healing (Adv. Healthcare Mater. 3/2024) |
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