Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys

Four new diterpenoids, phyllostachysins I-L （1-4）, along with a known one, hebeiabinin B （5）, were isolated from the aerial parts oflsodonphyllostachys （I.phyllostachys）. Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated...

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Veröffentlicht in:	Science China. Chemistry 2016-09, Vol.59 (9), p.1211-1215
Hauptverfasser:	Yang, Jin, An, Yaqi, Wu, Haiyan, Liu, Miao, Wang, Weiguang, Du, Xue, Li, Yan, Pu, Jianxin, Sun, Handong
Format:	Artikel
Sprache:	eng
Schlagworte:	A-549 Chemistry Chemistry and Materials Science Chemistry/Food Science HL-60 RAW264.7细胞二萜人乳腺癌细胞人肝癌细胞松香烷细胞毒活性
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Zusammenfassung:	Four new diterpenoids, phyllostachysins I-L （1-4）, along with a known one, hebeiabinin B （5）, were isolated from the aerial parts oflsodonphyllostachys （I.phyllostachys）. Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines （HL-60, SMMC-7721, A-549, MCF-7 and SW-480）, and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.
ISSN:	1674-7291 1869-1870
DOI:	10.1007/s11426-016-0049-4