Metal-free tetra-n-butylammonium bromide-mediated aerobic oxidative synthesis of β-ketosulfones from styrenes

An efficient and broadly applicable protocol for the aerobic coupling of styrenes with sulfonylhydrazides has been developed that affords P-ketosulfones bearing various functional groups in moderate to excellent yields.The preliminary experimental results support the involvement of active benzyl rad...

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Veröffentlicht in:Science China. Chemistry 2017-03, Vol.60 (3), p.353-357
Hauptverfasser: Wan, Xin, Sun, Kai, Zhang, Guisheng
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient and broadly applicable protocol for the aerobic coupling of styrenes with sulfonylhydrazides has been developed that affords P-ketosulfones bearing various functional groups in moderate to excellent yields.The preliminary experimental results support the involvement of active benzyl radical species,and a radical pathway was therefore proposed for the reaction.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-016-0284-2