Anti-inflammatory drug releasing absorbable surgical sutures using poly(lactic-co-glycolic acid) particle carriers

The goal of the current study was to develop an absorbable surgical suture incorporating poly(lactic- co -glycolic acid) (PLGA) particles loaded with dexamethasone (DEX) as an anti-inflammatory drug. DEX-loaded PLGA (DEX/PLGA) particles, prepared using a water-in-oil emulsion method, were electrosta...

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Veröffentlicht in:Polymer bulletin (Berlin, Germany) Germany), 2014-08, Vol.71 (8), p.1933-1946
Hauptverfasser: Lee, Du-Hyeong, Kwon, Tae-Yub, Kim, Kyo-Han, Kwon, Soon-Taek, Cho, Dae-Hyun, Jang, Soon Ho, Son, Jun Sik, Lee, Kyu-Bok
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container_end_page 1946
container_issue 8
container_start_page 1933
container_title Polymer bulletin (Berlin, Germany)
container_volume 71
creator Lee, Du-Hyeong
Kwon, Tae-Yub
Kim, Kyo-Han
Kwon, Soon-Taek
Cho, Dae-Hyun
Jang, Soon Ho
Son, Jun Sik
Lee, Kyu-Bok
description The goal of the current study was to develop an absorbable surgical suture incorporating poly(lactic- co -glycolic acid) (PLGA) particles loaded with dexamethasone (DEX) as an anti-inflammatory drug. DEX-loaded PLGA (DEX/PLGA) particles, prepared using a water-in-oil emulsion method, were electrostatically immobilized onto the surface of absorbable sutures. The surfaces of these DEX/PLGA particles were coated with positively charged polyethyleneimine (PEI) molecules, which imparted a net positive surface charge. These modified PEI-coated DEX/PLGA (PEI/DEX/PLGA) particles were then immobilized on negatively charged absorbable suture surfaces by electrostatic attraction. The results showed that DEX was efficiently loaded into PLGA particles and that the surfaces of DEX/PLGA particles were successfully coated with PEI. PEI/DEX/PLGA particles were well dispersed and immobilized onto suture surfaces. In addition, PEI/DEX/PLGA particles remained adherent to suture surfaces in vitro and demonstrated sustained DEX release in phosphate-buffered saline (pH 7.4) at 37 °C for up to 28 days under static conditions. The tensile strength and elongation at break of PEI/DEX/PLGA particle-treated sutures were almost the same as that of non-treated control sutures. Findings of this study show that various therapeutic drugs could be efficiently incorporated into absorbable sutures using biodegradable polymeric particles, and suggest that the devised absorbable, drug-eluting, sutures offer a promising basis for a novel absorbable surgical suture system.
doi_str_mv 10.1007/s00289-014-1164-8
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DEX-loaded PLGA (DEX/PLGA) particles, prepared using a water-in-oil emulsion method, were electrostatically immobilized onto the surface of absorbable sutures. The surfaces of these DEX/PLGA particles were coated with positively charged polyethyleneimine (PEI) molecules, which imparted a net positive surface charge. These modified PEI-coated DEX/PLGA (PEI/DEX/PLGA) particles were then immobilized on negatively charged absorbable suture surfaces by electrostatic attraction. The results showed that DEX was efficiently loaded into PLGA particles and that the surfaces of DEX/PLGA particles were successfully coated with PEI. PEI/DEX/PLGA particles were well dispersed and immobilized onto suture surfaces. In addition, PEI/DEX/PLGA particles remained adherent to suture surfaces in vitro and demonstrated sustained DEX release in phosphate-buffered saline (pH 7.4) at 37 °C for up to 28 days under static conditions. The tensile strength and elongation at break of PEI/DEX/PLGA particle-treated sutures were almost the same as that of non-treated control sutures. 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Bull</addtitle><description>The goal of the current study was to develop an absorbable surgical suture incorporating poly(lactic- co -glycolic acid) (PLGA) particles loaded with dexamethasone (DEX) as an anti-inflammatory drug. DEX-loaded PLGA (DEX/PLGA) particles, prepared using a water-in-oil emulsion method, were electrostatically immobilized onto the surface of absorbable sutures. The surfaces of these DEX/PLGA particles were coated with positively charged polyethyleneimine (PEI) molecules, which imparted a net positive surface charge. These modified PEI-coated DEX/PLGA (PEI/DEX/PLGA) particles were then immobilized on negatively charged absorbable suture surfaces by electrostatic attraction. The results showed that DEX was efficiently loaded into PLGA particles and that the surfaces of DEX/PLGA particles were successfully coated with PEI. PEI/DEX/PLGA particles were well dispersed and immobilized onto suture surfaces. In addition, PEI/DEX/PLGA particles remained adherent to suture surfaces in vitro and demonstrated sustained DEX release in phosphate-buffered saline (pH 7.4) at 37 °C for up to 28 days under static conditions. The tensile strength and elongation at break of PEI/DEX/PLGA particle-treated sutures were almost the same as that of non-treated control sutures. 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Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Sutures</subject><subject>Technology of polymers</subject><subject>Technology. Biomaterials. 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Bull</stitle><date>2014-08-01</date><risdate>2014</risdate><volume>71</volume><issue>8</issue><spage>1933</spage><epage>1946</epage><pages>1933-1946</pages><issn>0170-0839</issn><eissn>1436-2449</eissn><coden>POBUDR</coden><abstract>The goal of the current study was to develop an absorbable surgical suture incorporating poly(lactic- co -glycolic acid) (PLGA) particles loaded with dexamethasone (DEX) as an anti-inflammatory drug. DEX-loaded PLGA (DEX/PLGA) particles, prepared using a water-in-oil emulsion method, were electrostatically immobilized onto the surface of absorbable sutures. The surfaces of these DEX/PLGA particles were coated with positively charged polyethyleneimine (PEI) molecules, which imparted a net positive surface charge. These modified PEI-coated DEX/PLGA (PEI/DEX/PLGA) particles were then immobilized on negatively charged absorbable suture surfaces by electrostatic attraction. The results showed that DEX was efficiently loaded into PLGA particles and that the surfaces of DEX/PLGA particles were successfully coated with PEI. PEI/DEX/PLGA particles were well dispersed and immobilized onto suture surfaces. In addition, PEI/DEX/PLGA particles remained adherent to suture surfaces in vitro and demonstrated sustained DEX release in phosphate-buffered saline (pH 7.4) at 37 °C for up to 28 days under static conditions. The tensile strength and elongation at break of PEI/DEX/PLGA particle-treated sutures were almost the same as that of non-treated control sutures. Findings of this study show that various therapeutic drugs could be efficiently incorporated into absorbable sutures using biodegradable polymeric particles, and suggest that the devised absorbable, drug-eluting, sutures offer a promising basis for a novel absorbable surgical suture system.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00289-014-1164-8</doi><tpages>14</tpages></addata></record>
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subjects Anti-inflammatory agents
Antimicrobial agents
Applied sciences
Bacterial infections
Biological and medical sciences
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Dexamethasone
Drugs
Efficiency
Elongation
Exact sciences and technology
Fibers and threads
Forms of application and semi-finished materials
Glycolic acid
Infections
Medical sciences
Organic Chemistry
Original Paper
Physical Chemistry
Polyethyleneimine
Polymer industry, paints, wood
Polymer Sciences
Polymers
Polyvinyl alcohol
Silk
Soft and Granular Matter
Surface charge
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Sutures
Technology of polymers
Technology. Biomaterials. Equipments
Tensile strength
title Anti-inflammatory drug releasing absorbable surgical sutures using poly(lactic-co-glycolic acid) particle carriers
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