Nafcillin release from poly(acrylic acid-co-methyl methacrylate) hydrogels

SummaryCopolymeric poly(acrylic acid-co-methyl methacrylate) hydrogels for three different compositions: (90/10), (80/20) and (60/40), have been studied. Drug release has been examined as a function of the hydrogel composition by HPLC (High Pressure Liquid Cromatography). The release experiments wer...

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Veröffentlicht in:	Polymer bulletin (Berlin, Germany) Germany), 2005-12, Vol.55 (6), p.403-409
Hauptverfasser:	KATIME, Issa, SAEZ, Virginia, HERNAEZ, Estibaliz
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic acid Applied sciences Biological and medical sciences Composition Exact sciences and technology General pharmacology Hydrogels Medical sciences Molecular diffusion Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymethyl methacrylate Properties and characterization Special properties (catalyst, reagent or carrier)
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Zusammenfassung:	SummaryCopolymeric poly(acrylic acid-co-methyl methacrylate) hydrogels for three different compositions: (90/10), (80/20) and (60/40), have been studied. Drug release has been examined as a function of the hydrogel composition by HPLC (High Pressure Liquid Cromatography). The release experiments were carried out at 37 °C. The fraction of available drug release was linear in t1/2. The values of the diffusional coefficient (0.50
ISSN:	0170-0839 1436-2449
DOI:	10.1007/s00289-005-0453-7