Preparation of β-Cyclodextrin-Dextran Polymers and their Use as Supramolecular Carrier Systems for Naproxen

SummaryDextran, previously activated by periodate oxidation, was grafted with mono-6-amino-6-deoxy-β-cyclodextrin, mono-6-ethylenediamino-6-deoxy-β-cyclodextrin, and mono-6-butylenediamino-6-deoxy-β-cyclodextrin by reductive alkylation in the presence of NaBH4. The polymers were able to form inclusi...

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Veröffentlicht in:	Polymer bulletin (Berlin, Germany) Germany), 2007-12, Vol.59 (5), p.597-605
Hauptverfasser:	Ramirez, Hector L., Valdivia, Aymara, Cao, Roberto, Fragoso, Alex, Torres Labandeira, Juan Jose, Baños, Maysa, Villalonga, Reynaldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclodextrins Dextrans Inclusion complexes Naproxen Oxidation Polymers Reductive alkylation
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Zusammenfassung:	SummaryDextran, previously activated by periodate oxidation, was grafted with mono-6-amino-6-deoxy-β-cyclodextrin, mono-6-ethylenediamino-6-deoxy-β-cyclodextrin, and mono-6-butylenediamino-6-deoxy-β-cyclodextrin by reductive alkylation in the presence of NaBH4. The polymers were able to form inclusion complexes with Naproxen, increasing the solubility of the drug by 2.2-2.6 folds. The β-cyclodextrin-grafted dextrans were used as macromolecular carriers for Naproxen, improving the “in vivo” anti-inflammatory activity of the drug.
ISSN:	0170-0839 1436-2449
DOI:	10.1007/s00289-007-0803-8