Synthesis of heterobifunctional poly(ethy1ene glycol)containing an acryloyl group at one end and anisocyanate group at the other end

SummaryA New heterobifunctional poly(ethylene glycol) (PEG) having a polymerizable acryloyl group at one end and an isocyanate group at the other end was prepared in three efficient steps from commercially available t–Boc–PEG–NH2. The end groups were characterized by 1H NMR and MALDI–TOF–MS spectroscopy. Conjugation of the resulting PEG onto dextran via stable urethane linkage gave the PEG graft polymer with an acryloyl group at the free end of the graft chain.