Zerumbone delivery to tumor cells via pH-sensitive polymeric micelles
This study aimed to develop a smart drug delivery system for zerumbone as an anticancer agent, to enhance its therapeutic efficacy against tumors. To this purpose, pH-sensitive polymer PEG-P(Asp-Hyd-Zer) was prepared by conjugating zerumbone to the side chain of the copolymer PEG-P(Asp-Hyd) via an a...
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| Veröffentlicht in: | Colloid and polymer science 2024-02, Vol.302 (2), p.237-251 |
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| container_title | Colloid and polymer science |
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| creator | Duong, Nguyen Thanh Thiet, Tran Dinh Anh, Tran Thi Phuong Thi Lan, Pham Anh, Nguyen Tuan Lam, Tran Dai |
| description | This study aimed to develop a smart drug delivery system for zerumbone as an anticancer agent, to enhance its therapeutic efficacy against tumors. To this purpose, pH-sensitive polymer PEG-P(Asp-Hyd-Zer) was prepared by conjugating zerumbone to the side chain of the copolymer PEG-P(Asp-Hyd) via an acid-labile hydrazone bond. The resulting micelles were prepared in an aqueous solution with the size of 60 nm in diameter. The zerumbone pH-sensitive micelles remained stable at physiological pH = 7.4 but could be degraded in the acidic environment of endosomal/lysosomal compartments (pH |
| doi_str_mv | 10.1007/s00396-023-05191-1 |
| format | Article |
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To this purpose, pH-sensitive polymer PEG-P(Asp-Hyd-Zer) was prepared by conjugating zerumbone to the side chain of the copolymer PEG-P(Asp-Hyd) via an acid-labile hydrazone bond. The resulting micelles were prepared in an aqueous solution with the size of 60 nm in diameter. The zerumbone pH-sensitive micelles remained stable at physiological pH = 7.4 but could be degraded in the acidic environment of endosomal/lysosomal compartments (pH < 6.0), allowing for targeted delivery of zerumbone to tumor cells. The release of zerumbone from the zerumbone pH-sensitive micelles was controlled by pH of the medium, with faster release observed under acidic conditions. In vitro and in vivo tests demonstrated that these zerumbone pH-sensitive micelles effectively induced cancer cell destruction under weakly acidic tumoral conditions, highlighting their potential as an effective delivery system for zerumbone. 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To this purpose, pH-sensitive polymer PEG-P(Asp-Hyd-Zer) was prepared by conjugating zerumbone to the side chain of the copolymer PEG-P(Asp-Hyd) via an acid-labile hydrazone bond. The resulting micelles were prepared in an aqueous solution with the size of 60 nm in diameter. The zerumbone pH-sensitive micelles remained stable at physiological pH = 7.4 but could be degraded in the acidic environment of endosomal/lysosomal compartments (pH < 6.0), allowing for targeted delivery of zerumbone to tumor cells. The release of zerumbone from the zerumbone pH-sensitive micelles was controlled by pH of the medium, with faster release observed under acidic conditions. In vitro and in vivo tests demonstrated that these zerumbone pH-sensitive micelles effectively induced cancer cell destruction under weakly acidic tumoral conditions, highlighting their potential as an effective delivery system for zerumbone. 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| subjects | Anticancer properties Aqueous solutions Biomedical materials Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Copolymers Drug delivery systems Food Science Hydrazones In vivo methods and tests Micelles Nanotechnology and Microengineering Pharmacology Physical Chemistry Polymer Sciences Soft and Granular Matter |
| title | Zerumbone delivery to tumor cells via pH-sensitive polymeric micelles |
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