Zerumbone delivery to tumor cells via pH-sensitive polymeric micelles

Zerumbone delivery to tumor cells via pH-sensitive polymeric micelles

This study aimed to develop a smart drug delivery system for zerumbone as an anticancer agent, to enhance its therapeutic efficacy against tumors. To this purpose, pH-sensitive polymer PEG-P(Asp-Hyd-Zer) was prepared by conjugating zerumbone to the side chain of the copolymer PEG-P(Asp-Hyd) via an a...

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Veröffentlicht in:Colloid and polymer science 2024-02, Vol.302 (2), p.237-251
Hauptverfasser: Duong, Nguyen Thanh, Thiet, Tran Dinh, Anh, Tran Thi Phuong, Thi Lan, Pham, Anh, Nguyen Tuan, Lam, Tran Dai
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Aqueous solutions
Biomedical materials
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Copolymers
Drug delivery systems
Food Science
Hydrazones
In vivo methods and tests
Micelles
Nanotechnology and Microengineering
Pharmacology
Physical Chemistry
Polymer Sciences
Soft and Granular Matter
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Zusammenfassung:This study aimed to develop a smart drug delivery system for zerumbone as an anticancer agent, to enhance its therapeutic efficacy against tumors. To this purpose, pH-sensitive polymer PEG-P(Asp-Hyd-Zer) was prepared by conjugating zerumbone to the side chain of the copolymer PEG-P(Asp-Hyd) via an acid-labile hydrazone bond. The resulting micelles were prepared in an aqueous solution with the size of 60 nm in diameter. The zerumbone pH-sensitive micelles remained stable at physiological pH = 7.4 but could be degraded in the acidic environment of endosomal/lysosomal compartments (pH 
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-023-05191-1