Front Cover: Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication (ChemMedChem 2/2024)

The Front Cover represents inhibition by the peptidomimetic compound 15m of the influenza activating human protease matriptase expressed in cells of the respiratory tract. The trimeric H1 hemagglutinin (HA) viral protein (top left) is cleaved by type II transmembrane serine proteases such as matriptase (bottom right) to enable viral entry. Interaction between 15m (green) and matriptase as well as the HA cleavage sequence (orange) is magnified in the central inset. Cover art designed by Malihe Hassanzadeh. More information can be found in the Research Article by Éloïc Colombo, Antoine Désilets, Richard Leduc, Pierre‐Luc Boudreault et al.