Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles
The hybrid molecules were obtained by N -alkylation of piperidines, piperazines, tetrahydroisoquinoline, morpholine and phthalimide using N -chloroacetamide derivatives of 2,2,4-trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline. The prepared compounds show moderate inhibitory activity in relation to the...
Gespeichert in:
| Veröffentlicht in: | Russian journal of general chemistry 2023-12, Vol.93 (Suppl 2), p.S501-S509 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S509 |
|---|---|
| container_issue | Suppl 2 |
| container_start_page | S501 |
| container_title | Russian journal of general chemistry |
| container_volume | 93 |
| creator | Potapov, M. A. Novichikhina, N. P. Shestakov, A. S. Shikhalieva, K. D. Podoplelova, N. A. Panteleev, M. A. Shikhaliev, Kh. S. |
| description | The hybrid molecules were obtained by
N
-alkylation of piperidines, piperazines, tetrahydroisoquinoline, morpholine and phthalimide using
N
-chloroacetamide derivatives of 2,2,4-trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline. The prepared compounds show moderate inhibitory activity in relation to the blood coagulation factor Xa. |
| doi_str_mv | 10.1134/S1070363223150124 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2913117481</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A779104101</galeid><sourcerecordid>A779104101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c335t-9af172654d2da3e0fe55e009dd9733693ecde9133aff3921021e1d554b1e3e713</originalsourceid><addsrcrecordid>eNp1UctOHDEQHKFE4pF8QG6WuGJw2_NgjsuKZJEIHIDzyNjtwWjWJrYXab4hP51ebSQShciHtrqq-lFdVV9AnAKo-uwORCdUq6RU0AiQ9V51AK0450o14gP9CeZbfL86zPlZCBCilQfVz0Uo3kQ9biYdCluY4l99mVl0bDU_Jm_Z9zih2UyY2YXOaFkMTJ7Ik5rfJ7_G8jRPvOY6UQBKKwIKlqSfZpvij40PcfIBmQ6W3fiS4oiBL2Mo2gcfRrbCgima2VCDT9VHp6eMn3_Ho-rh6-X9csWvb79dLRfX3NAyhffaQSfbprbSaoXCYdOgEL21fadU2ys0FntQSjuneglCAoJtmvoRUGEH6qg63tV92U6IuQzPcZMCtRwk6QC6-vwP1qgnHHxwkbYya5_NsOi6HkQNYss6fYdFz-KafA3oPOX_EsBOYFLMOaEbXshH8m8AMWxPOfxzStLInSYTN4yY3gb-v-gXhbid4A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2913117481</pqid></control><display><type>article</type><title>Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles</title><source>Springer Nature - Complete Springer Journals</source><creator>Potapov, M. A. ; Novichikhina, N. P. ; Shestakov, A. S. ; Shikhalieva, K. D. ; Podoplelova, N. A. ; Panteleev, M. A. ; Shikhaliev, Kh. S.</creator><creatorcontrib>Potapov, M. A. ; Novichikhina, N. P. ; Shestakov, A. S. ; Shikhalieva, K. D. ; Podoplelova, N. A. ; Panteleev, M. A. ; Shikhaliev, Kh. S.</creatorcontrib><description>The hybrid molecules were obtained by
N
-alkylation of piperidines, piperazines, tetrahydroisoquinoline, morpholine and phthalimide using
N
-chloroacetamide derivatives of 2,2,4-trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline. The prepared compounds show moderate inhibitory activity in relation to the blood coagulation factor Xa.</description><identifier>ISSN: 1070-3632</identifier><identifier>EISSN: 1608-3350</identifier><identifier>DOI: 10.1134/S1070363223150124</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Alkylation ; Anticoagulants (Medicine) ; Aromatic compounds ; Blood coagulation ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Nitrogen ; Phthalimides</subject><ispartof>Russian journal of general chemistry, 2023-12, Vol.93 (Suppl 2), p.S501-S509</ispartof><rights>Pleiades Publishing, Ltd. 2023</rights><rights>COPYRIGHT 2023 Springer</rights><rights>Pleiades Publishing, Ltd. 2023.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-9af172654d2da3e0fe55e009dd9733693ecde9133aff3921021e1d554b1e3e713</cites><orcidid>0000-0002-8128-7757 ; 0000-0002-1795-7605 ; 0009-0009-1428-4757 ; 0000-0002-6576-0305 ; 0000-0001-8167-6093 ; 0000-0002-0426-4789</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070363223150124$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070363223150124$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids></links><search><creatorcontrib>Potapov, M. A.</creatorcontrib><creatorcontrib>Novichikhina, N. P.</creatorcontrib><creatorcontrib>Shestakov, A. S.</creatorcontrib><creatorcontrib>Shikhalieva, K. D.</creatorcontrib><creatorcontrib>Podoplelova, N. A.</creatorcontrib><creatorcontrib>Panteleev, M. A.</creatorcontrib><creatorcontrib>Shikhaliev, Kh. S.</creatorcontrib><title>Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles</title><title>Russian journal of general chemistry</title><addtitle>Russ J Gen Chem</addtitle><description>The hybrid molecules were obtained by
N
-alkylation of piperidines, piperazines, tetrahydroisoquinoline, morpholine and phthalimide using
N
-chloroacetamide derivatives of 2,2,4-trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline. The prepared compounds show moderate inhibitory activity in relation to the blood coagulation factor Xa.</description><subject>Alkylation</subject><subject>Anticoagulants (Medicine)</subject><subject>Aromatic compounds</subject><subject>Blood coagulation</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Nitrogen</subject><subject>Phthalimides</subject><issn>1070-3632</issn><issn>1608-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1UctOHDEQHKFE4pF8QG6WuGJw2_NgjsuKZJEIHIDzyNjtwWjWJrYXab4hP51ebSQShciHtrqq-lFdVV9AnAKo-uwORCdUq6RU0AiQ9V51AK0450o14gP9CeZbfL86zPlZCBCilQfVz0Uo3kQ9biYdCluY4l99mVl0bDU_Jm_Z9zih2UyY2YXOaFkMTJ7Ik5rfJ7_G8jRPvOY6UQBKKwIKlqSfZpvij40PcfIBmQ6W3fiS4oiBL2Mo2gcfRrbCgima2VCDT9VHp6eMn3_Ho-rh6-X9csWvb79dLRfX3NAyhffaQSfbprbSaoXCYdOgEL21fadU2ys0FntQSjuneglCAoJtmvoRUGEH6qg63tV92U6IuQzPcZMCtRwk6QC6-vwP1qgnHHxwkbYya5_NsOi6HkQNYss6fYdFz-KafA3oPOX_EsBOYFLMOaEbXshH8m8AMWxPOfxzStLInSYTN4yY3gb-v-gXhbid4A</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Potapov, M. A.</creator><creator>Novichikhina, N. P.</creator><creator>Shestakov, A. S.</creator><creator>Shikhalieva, K. D.</creator><creator>Podoplelova, N. A.</creator><creator>Panteleev, M. A.</creator><creator>Shikhaliev, Kh. S.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8128-7757</orcidid><orcidid>https://orcid.org/0000-0002-1795-7605</orcidid><orcidid>https://orcid.org/0009-0009-1428-4757</orcidid><orcidid>https://orcid.org/0000-0002-6576-0305</orcidid><orcidid>https://orcid.org/0000-0001-8167-6093</orcidid><orcidid>https://orcid.org/0000-0002-0426-4789</orcidid></search><sort><creationdate>20231201</creationdate><title>Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles</title><author>Potapov, M. A. ; Novichikhina, N. P. ; Shestakov, A. S. ; Shikhalieva, K. D. ; Podoplelova, N. A. ; Panteleev, M. A. ; Shikhaliev, Kh. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-9af172654d2da3e0fe55e009dd9733693ecde9133aff3921021e1d554b1e3e713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alkylation</topic><topic>Anticoagulants (Medicine)</topic><topic>Aromatic compounds</topic><topic>Blood coagulation</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Nitrogen</topic><topic>Phthalimides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Potapov, M. A.</creatorcontrib><creatorcontrib>Novichikhina, N. P.</creatorcontrib><creatorcontrib>Shestakov, A. S.</creatorcontrib><creatorcontrib>Shikhalieva, K. D.</creatorcontrib><creatorcontrib>Podoplelova, N. A.</creatorcontrib><creatorcontrib>Panteleev, M. A.</creatorcontrib><creatorcontrib>Shikhaliev, Kh. S.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of general chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Potapov, M. A.</au><au>Novichikhina, N. P.</au><au>Shestakov, A. S.</au><au>Shikhalieva, K. D.</au><au>Podoplelova, N. A.</au><au>Panteleev, M. A.</au><au>Shikhaliev, Kh. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles</atitle><jtitle>Russian journal of general chemistry</jtitle><stitle>Russ J Gen Chem</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>93</volume><issue>Suppl 2</issue><spage>S501</spage><epage>S509</epage><pages>S501-S509</pages><issn>1070-3632</issn><eissn>1608-3350</eissn><abstract>The hybrid molecules were obtained by
N
-alkylation of piperidines, piperazines, tetrahydroisoquinoline, morpholine and phthalimide using
N
-chloroacetamide derivatives of 2,2,4-trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline. The prepared compounds show moderate inhibitory activity in relation to the blood coagulation factor Xa.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363223150124</doi><orcidid>https://orcid.org/0000-0002-8128-7757</orcidid><orcidid>https://orcid.org/0000-0002-1795-7605</orcidid><orcidid>https://orcid.org/0009-0009-1428-4757</orcidid><orcidid>https://orcid.org/0000-0002-6576-0305</orcidid><orcidid>https://orcid.org/0000-0001-8167-6093</orcidid><orcidid>https://orcid.org/0000-0002-0426-4789</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1070-3632 |
| ispartof | Russian journal of general chemistry, 2023-12, Vol.93 (Suppl 2), p.S501-S509 |
| issn | 1070-3632 1608-3350 |
| language | eng |
| recordid | cdi_proquest_journals_2913117481 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Alkylation Anticoagulants (Medicine) Aromatic compounds Blood coagulation Chemistry Chemistry and Materials Science Chemistry/Food Science Nitrogen Phthalimides |
| title | Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T20%3A52%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anticoagulant%20Activity%20of%20Hybrid%20Molecules%20Based%20on%202,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline%20and%20Nitrogen-Containing%20Heterocycles&rft.jtitle=Russian%20journal%20of%20general%20chemistry&rft.au=Potapov,%20M.%20A.&rft.date=2023-12-01&rft.volume=93&rft.issue=Suppl%202&rft.spage=S501&rft.epage=S509&rft.pages=S501-S509&rft.issn=1070-3632&rft.eissn=1608-3350&rft_id=info:doi/10.1134/S1070363223150124&rft_dat=%3Cgale_proqu%3EA779104101%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2913117481&rft_id=info:pmid/&rft_galeid=A779104101&rfr_iscdi=true |