Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles

Anticoagulant Activity of Hybrid Molecules Based on 2,2,4-Trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline and Nitrogen-Containing Heterocycles

The hybrid molecules were obtained by N -alkylation of piperidines, piperazines, tetrahydroisoquinoline, morpholine and phthalimide using N -chloroacetamide derivatives of 2,2,4-trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline. The prepared compounds show moderate inhibitory activity in relation to the...

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Veröffentlicht in:Russian journal of general chemistry 2023-12, Vol.93 (Suppl 2), p.S501-S509
Hauptverfasser: Potapov, M. A., Novichikhina, N. P., Shestakov, A. S., Shikhalieva, K. D., Podoplelova, N. A., Panteleev, M. A., Shikhaliev, Kh. S.
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Anticoagulants (Medicine)
Aromatic compounds
Blood coagulation
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Nitrogen
Phthalimides
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Zusammenfassung:The hybrid molecules were obtained by N -alkylation of piperidines, piperazines, tetrahydroisoquinoline, morpholine and phthalimide using N -chloroacetamide derivatives of 2,2,4-trimethyl-4-aryl-1,2,3,4-tetrahydroquinoline. The prepared compounds show moderate inhibitory activity in relation to the blood coagulation factor Xa.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363223150124