Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine
A series of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl) pyridine ( Va–Vj ) was synthesized by reaction of 2-(trifluoromethyl) pyridine-3-carbohydrazide ( III ) with different substituted benzoic acids ( IVa–IVj ) in phosphorous oxychloride, obtained compounds were characterized b...
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| Veröffentlicht in: | Russian journal of bioorganic chemistry 2023-12, Vol.49 (Suppl 1), p.S171-S178 |
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| container_end_page | S178 |
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| container_issue | Suppl 1 |
| container_start_page | S171 |
| container_title | Russian journal of bioorganic chemistry |
| container_volume | 49 |
| creator | Dhotre, B. K. Raut, S. V. Farooqui, M. Jadhav, S. B. Pathan, A. |
| description | A series of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl) pyridine (
Va–Vj
) was synthesized by reaction of 2-(trifluoromethyl) pyridine-3-carbohydrazide (
III
) with different substituted benzoic acids (
IVa–IVj
) in phosphorous oxychloride, obtained compounds were characterized by spectral data. Subsequently, these compounds were tested for their
in vitro
antifungal activities against
C. albicans
and
A. niger
by agar diffusion method, some compounds displayed good antifungal activity when compared with fluconazole. These compounds were also screened for their anti-tubercular activities against primary
Mycobacterium smegmatis
mc
2
155. The compounds (
Vg
) and (
Vh
) exhibits promising activity with MICs 91 and 109 μg/mL respectively. |
| doi_str_mv | 10.1134/S1068162023080149 |
| format | Article |
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Va–Vj
) was synthesized by reaction of 2-(trifluoromethyl) pyridine-3-carbohydrazide (
III
) with different substituted benzoic acids (
IVa–IVj
) in phosphorous oxychloride, obtained compounds were characterized by spectral data. Subsequently, these compounds were tested for their
in vitro
antifungal activities against
C. albicans
and
A. niger
by agar diffusion method, some compounds displayed good antifungal activity when compared with fluconazole. These compounds were also screened for their anti-tubercular activities against primary
Mycobacterium smegmatis
mc
2
155. The compounds (
Vg
) and (
Vh
) exhibits promising activity with MICs 91 and 109 μg/mL respectively.</description><identifier>ISSN: 1068-1620</identifier><identifier>EISSN: 1608-330X</identifier><identifier>DOI: 10.1134/S1068162023080149</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Benzoic acid ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Chemical synthesis ; Fungicides ; Life Sciences ; Organic Chemistry ; Pyridines ; Substitutes</subject><ispartof>Russian journal of bioorganic chemistry, 2023-12, Vol.49 (Suppl 1), p.S171-S178</ispartof><rights>Pleiades Publishing, Ltd. 2023</rights><rights>Pleiades Publishing, Ltd. 2023.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c268t-f2945e68efb004bca085b64e5ffd9b67fbee6dd135bdb4129fe5a0cebcf09f4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1068162023080149$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1068162023080149$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Dhotre, B. K.</creatorcontrib><creatorcontrib>Raut, S. V.</creatorcontrib><creatorcontrib>Farooqui, M.</creatorcontrib><creatorcontrib>Jadhav, S. B.</creatorcontrib><creatorcontrib>Pathan, A.</creatorcontrib><title>Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine</title><title>Russian journal of bioorganic chemistry</title><addtitle>Russ J Bioorg Chem</addtitle><description>A series of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl) pyridine (
Va–Vj
) was synthesized by reaction of 2-(trifluoromethyl) pyridine-3-carbohydrazide (
III
) with different substituted benzoic acids (
IVa–IVj
) in phosphorous oxychloride, obtained compounds were characterized by spectral data. Subsequently, these compounds were tested for their
in vitro
antifungal activities against
C. albicans
and
A. niger
by agar diffusion method, some compounds displayed good antifungal activity when compared with fluconazole. These compounds were also screened for their anti-tubercular activities against primary
Mycobacterium smegmatis
mc
2
155. The compounds (
Vg
) and (
Vh
) exhibits promising activity with MICs 91 and 109 μg/mL respectively.</description><subject>Benzoic acid</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Chemical synthesis</subject><subject>Fungicides</subject><subject>Life Sciences</subject><subject>Organic Chemistry</subject><subject>Pyridines</subject><subject>Substitutes</subject><issn>1068-1620</issn><issn>1608-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kM1Lw0AQxYMoWKt_gLeAlwpZnf1ImhxL8QsKHqrgLewms-2WNKm7GzEe_NtNrOBBPM0w7_fewAuCcwpXlHJxvaSQpDRhwDikQEV2EIxoAinhHF4O-72XyaAfByfObQAoQJyOgs9lV_s1OuOicFZ741uFtmgraaNQ1uX3Tbf1SlbhrPDmzfgubHTIyMRbo6u2sc0W_bqrLgknE9cqN2R4LMPdGuuuIjTikSDNuyyN_GgqwsjA7jprSlPjaXCkZeXw7GeOg-fbm6f5PVk83j3MZwtSsCT1RLNMxJikqBWAUIWENFaJwFjrMlPJVCvEpCwpj1WpBGWZxlhCgarQkGmh-Ti42OfubPPaovP5pmlt3b_MWUY5pVMmWE_RPVXYxjmLOt9Zs5W2yynkQ835n5p7D9t7XM_WK7S_yf-bvgAMPICD</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Dhotre, B. K.</creator><creator>Raut, S. V.</creator><creator>Farooqui, M.</creator><creator>Jadhav, S. B.</creator><creator>Pathan, A.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20231201</creationdate><title>Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine</title><author>Dhotre, B. K. ; Raut, S. V. ; Farooqui, M. ; Jadhav, S. B. ; Pathan, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c268t-f2945e68efb004bca085b64e5ffd9b67fbee6dd135bdb4129fe5a0cebcf09f4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Benzoic acid</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Chemical synthesis</topic><topic>Fungicides</topic><topic>Life Sciences</topic><topic>Organic Chemistry</topic><topic>Pyridines</topic><topic>Substitutes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dhotre, B. K.</creatorcontrib><creatorcontrib>Raut, S. V.</creatorcontrib><creatorcontrib>Farooqui, M.</creatorcontrib><creatorcontrib>Jadhav, S. B.</creatorcontrib><creatorcontrib>Pathan, A.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of bioorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dhotre, B. K.</au><au>Raut, S. V.</au><au>Farooqui, M.</au><au>Jadhav, S. B.</au><au>Pathan, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine</atitle><jtitle>Russian journal of bioorganic chemistry</jtitle><stitle>Russ J Bioorg Chem</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>49</volume><issue>Suppl 1</issue><spage>S171</spage><epage>S178</epage><pages>S171-S178</pages><issn>1068-1620</issn><eissn>1608-330X</eissn><abstract>A series of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl) pyridine (
Va–Vj
) was synthesized by reaction of 2-(trifluoromethyl) pyridine-3-carbohydrazide (
III
) with different substituted benzoic acids (
IVa–IVj
) in phosphorous oxychloride, obtained compounds were characterized by spectral data. Subsequently, these compounds were tested for their
in vitro
antifungal activities against
C. albicans
and
A. niger
by agar diffusion method, some compounds displayed good antifungal activity when compared with fluconazole. These compounds were also screened for their anti-tubercular activities against primary
Mycobacterium smegmatis
mc
2
155. The compounds (
Vg
) and (
Vh
) exhibits promising activity with MICs 91 and 109 μg/mL respectively.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1068162023080149</doi></addata></record> |
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| subjects | Benzoic acid Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Chemical synthesis Fungicides Life Sciences Organic Chemistry Pyridines Substitutes |
| title | Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine |
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