Synthesis, Antitubercular, and Antifungal Activity of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl)-pyridine

A series of 2-(trifluoromethyl)-3-(substituted phenyl-1,3,4-oxadiazol-2-yl) pyridine ( Va–Vj ) was synthesized by reaction of 2-(trifluoromethyl) pyridine-3-carbohydrazide ( III ) with different substituted benzoic acids ( IVa–IVj ) in phosphorous oxychloride, obtained compounds were characterized by spectral data. Subsequently, these compounds were tested for their in vitro antifungal activities against C. albicans and A. niger by agar diffusion method, some compounds displayed good antifungal activity when compared with fluconazole. These compounds were also screened for their anti-tubercular activities against primary Mycobacterium smegmatis mc 2 155. The compounds ( Vg ) and ( Vh ) exhibits promising activity with MICs 91 and 109 μg/mL respectively.