Radical‐Mediated 1,2‐Difunctionalization of Alkenes with Nucleophiles and Acetonitrile through C(sp3)−H Bond Cleavage

Radical‐Mediated 1,2‐Difunctionalization of Alkenes with Nucleophiles and Acetonitrile through C(sp3)−H Bond Cleavage

A cobalt‐catalyzed intermolecular 1,2‐difunctionalization of alkenes with anilines/indoles and acetonitrile has been developed. This protocol provides an access to functionalized cyano‐containing molecules. In this transformation, employing di‐tert‐butyl peroxide as a radical initiator, a variety of...

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Veröffentlicht in:Advanced synthesis & catalysis 2024-01, Vol.366 (1), p.56-61
Hauptverfasser: Zhu, Fengxiang, Yang, Yifan, Shi, Shanshan
Format: Artikel
Sprache:eng
Schlagworte:
1,2-Difunctionalization
Acetonitrile
Alkene
Alkenes
Aniline
Aromatic compounds
C(sp3)−H bond cleavage
Cobalt
Commercialization
Indoles
Isotope effect
Multicomponent reaction
Nucleophiles
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Zusammenfassung:A cobalt‐catalyzed intermolecular 1,2‐difunctionalization of alkenes with anilines/indoles and acetonitrile has been developed. This protocol provides an access to functionalized cyano‐containing molecules. In this transformation, employing di‐tert‐butyl peroxide as a radical initiator, a variety of commercialized nucleophiles and electronically diverse arenes were well tolerated. In addition, we also studied the kinetic isotope effect.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202300956